中国体育科技
中國體育科技
중국체육과기
China Sport Science and Technology
2012年
2期
91~95
,共null页
高脂血症 洛伐他汀 跑步强度 鼠 动物实验
高脂血癥 洛伐他汀 跑步彊度 鼠 動物實驗
고지혈증 락벌타정 포보강도 서 동물실험
hyperli pidemia ; Lovastatin ; running intensity ; mice ; animal experiments
目的：研究不同运动强度对高脂血症小鼠血脂反应及代谢的影响,阐明运动对高脂血症小鼠提供非药物治疗的一种方便可行的调节机制。方法：通过小鼠建模对照实验,随机分为正常对照组、洛伐他汀治疗组、高脂模型组及跑步干预组4组对照。对跑步干预组又进行高、中、低3种强度的跑步运动,21天后测定血清、肝的胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）,得到数据并分析。结果：跑步干预21天后,高脂模型组的小鼠的血清、肝脏的TC、TG水平均高于跑步干预的3组和洛伐他汀治疗组;高强度跑步干预组各项指标与洛伐他汀治疗组相近且接近正常对照组。结论：跑步运动在高强度情况下对降脂有明显效果,与洛伐他汀治疗组相比无显著性差异;中、低强度情况下效果不明显,因此,高强度的运动能有效地预防及治疗高脂血症。
目的：研究不同運動彊度對高脂血癥小鼠血脂反應及代謝的影響,闡明運動對高脂血癥小鼠提供非藥物治療的一種方便可行的調節機製。方法：通過小鼠建模對照實驗,隨機分為正常對照組、洛伐他汀治療組、高脂模型組及跑步榦預組4組對照。對跑步榦預組又進行高、中、低3種彊度的跑步運動,21天後測定血清、肝的膽固醇（TC）、甘油三酯（TG）、高密度脂蛋白膽固醇（HDL-C）,得到數據併分析。結果：跑步榦預21天後,高脂模型組的小鼠的血清、肝髒的TC、TG水平均高于跑步榦預的3組和洛伐他汀治療組;高彊度跑步榦預組各項指標與洛伐他汀治療組相近且接近正常對照組。結論：跑步運動在高彊度情況下對降脂有明顯效果,與洛伐他汀治療組相比無顯著性差異;中、低彊度情況下效果不明顯,因此,高彊度的運動能有效地預防及治療高脂血癥。
목적：연구불동운동강도대고지혈증소서혈지반응급대사적영향,천명운동대고지혈증소서제공비약물치료적일충방편가행적조절궤제。방법：통과소서건모대조실험,수궤분위정상대조조、락벌타정치료조、고지모형조급포보간예조4조대조。대포보간예조우진행고、중、저3충강도적포보운동,21천후측정혈청、간적담고순（TC）、감유삼지（TG）、고밀도지단백담고순（HDL-C）,득도수거병분석。결과：포보간예21천후,고지모형조적소서적혈청、간장적TC、TG수평균고우포보간예적3조화락벌타정치료조;고강도포보간예조각항지표여락벌타정치료조상근차접근정상대조조。결론：포보운동재고강도정황하대강지유명현효과,여락벌타정치료조상비무현저성차이;중、저강도정황하효과불명현,인차,고강도적운동능유효지예방급치료고지혈증。
Objective.. To study the influence of different exercise intensities on reaction and high blood lipid metabolism in hyperlipidemia in mice and explain the regulation mechanisms of exercise on hyperlipidemia in mice with providing a convenient non-pharmacological treatment, Methods：Modeling of control experiments in mice was randomly divided into normal control group, lovastatin treatment group, model group and four groups were run in the intervention group. Intervention group was on the run for high, medium, and low-intensity treadmill exer- cise, 21 d after the serum, liver cholesterol （TC）, triglyceride （TG）, high-density lipoprotein targets （HDL-C）, and data obtained was analyzed. Results： After running 21d intervention, model group mice serum, liver TC, TG were higher than running the three intervention groups and lovastatin treatment group; High-intensity running in the intervention group and the lovas- tatin treatment group, the indicators are similar and close to the normal control group. Conclu- sion ： Running in the case of high intensity had a marked effect on lipid-lowering with lovastatin treatment group showed no significant difference; In the case of low-intensity, the effect is not obvious, so the high-intensity exercise can be effective prevention and treatment of hyperlipidemia.
