体育科学
體育科學
체육과학
China Sport Science
2012年
6期
69~73
,共null页
马国栋 铁钰 刘艳环 王秋灵 赵宁
馬國棟 鐵鈺 劉豔環 王鞦靈 趙寧
마국동 철옥 류염배 왕추령 조저
耐力训练 脂肪质量与肥胖相关基因 大鼠 摄食量
耐力訓練 脂肪質量與肥胖相關基因 大鼠 攝食量
내력훈련 지방질량여비반상관기인 대서 섭식량
endurance training ; fat mass and obesity-associated protein gene ; rats ; food intake
目的：研究耐力训练对大鼠FTO基因表达的影响以及与摄食量的关系。方法：以SD大鼠为研究对象，将大鼠分为对照组（C组）和运动训练组（E组），以12周无负重游泳为运动手段，测定肝脏、骨骼肌、脂肪组织和下丘脑组织中FTO基因mRNA表达、大鼠体重、肾周与附睾周围脂肪重量及脂肪重量与体重百分比、大鼠每天摄食量。结果：FTD基因reRAN在骨骼肌、脂肪组织和下丘脑中表达均显著高于肝脏组织，下丘脑显著高于骨骼肌和脂肪组织，脂肪组织与骨骼肌未见显著性差异，耐力训练对肝脏、骨骼肌和脂肪组织中FTO基因mRNA表达未见显著性影响，而脑组织表达显著升高；大鼠体重在不同的对应时间点，运动训练组与对照组未见显著性差异；大鼠摄食量在不同对应时间点，运动训练组显著高于对照组；肾周及附睾周围脂肪组织重量及脂肪重与体重百分比运动训练组显著低于对照组。结论：耐力训练可以提高下丘脑中FTD基因表达，从而刺激大鼠提高摄食量，而运动能量的消耗抵消了因摄食增加引起的体重增加。
目的：研究耐力訓練對大鼠FTO基因錶達的影響以及與攝食量的關繫。方法：以SD大鼠為研究對象，將大鼠分為對照組（C組）和運動訓練組（E組），以12週無負重遊泳為運動手段，測定肝髒、骨骼肌、脂肪組織和下丘腦組織中FTO基因mRNA錶達、大鼠體重、腎週與附睪週圍脂肪重量及脂肪重量與體重百分比、大鼠每天攝食量。結果：FTD基因reRAN在骨骼肌、脂肪組織和下丘腦中錶達均顯著高于肝髒組織，下丘腦顯著高于骨骼肌和脂肪組織，脂肪組織與骨骼肌未見顯著性差異，耐力訓練對肝髒、骨骼肌和脂肪組織中FTO基因mRNA錶達未見顯著性影響，而腦組織錶達顯著升高；大鼠體重在不同的對應時間點，運動訓練組與對照組未見顯著性差異；大鼠攝食量在不同對應時間點，運動訓練組顯著高于對照組；腎週及附睪週圍脂肪組織重量及脂肪重與體重百分比運動訓練組顯著低于對照組。結論：耐力訓練可以提高下丘腦中FTD基因錶達，從而刺激大鼠提高攝食量，而運動能量的消耗牴消瞭因攝食增加引起的體重增加。
목적：연구내력훈련대대서FTO기인표체적영향이급여섭식량적관계。방법：이SD대서위연구대상，장대서분위대조조（C조）화운동훈련조（E조），이12주무부중유영위운동수단，측정간장、골격기、지방조직화하구뇌조직중FTO기인mRNA표체、대서체중、신주여부고주위지방중량급지방중량여체중백분비、대서매천섭식량。결과：FTD기인reRAN재골격기、지방조직화하구뇌중표체균현저고우간장조직，하구뇌현저고우골격기화지방조직，지방조직여골격기미견현저성차이，내력훈련대간장、골격기화지방조직중FTO기인mRNA표체미견현저성영향，이뇌조직표체현저승고；대서체중재불동적대응시간점，운동훈련조여대조조미견현저성차이；대서섭식량재불동대응시간점，운동훈련조현저고우대조조；신주급부고주위지방조직중량급지방중여체중백분비운동훈련조현저저우대조조。결론：내력훈련가이제고하구뇌중FTD기인표체，종이자격대서제고섭식량，이운동능량적소모저소료인섭식증가인기적체중증가。
Objective： To investigate the relationship between FTO gene expression and intake food by endurance training in rats. Methods：The rats were randomly divided into control and endurance trained group. This paper analyzed the mRNA expression of FTO in liver and skeletal muscle, adipose tissue and hypothalamus, body weight, adipose tissue weight around kidney and epididymis, average food intake per day in rats after 12 week unload swimming training. Results ： The Fro gene mRNA expressions in skeletal muscle, adipose tissue and hypothalamus were higher than in liver, its expression in hypothalamus was higher than in skeletal muscle and adipose tissue, but its expression in skeletal muscle and adipose tissue was no significant dif- ferent. Endurance training up-regulated FTO gene expression in hypothalamus, however, there was no change in skeletal muscle,liver and adipose tissue. The rat weight was no significant different in parallel time point, but food intake significantly increased in trained rats. Adipose tissue weight around kidney and epididymis decreased significantly in trained rats. Conclusion： Endurance training increased the FTO gene expression in hypothalamus which stimulated more food intake. However, the rat weight was no change for exercise expending more energy.
