CAJ | 학술논문

创制理想的动物模型是突破抑郁症研究的技术难点之一。来自进化研究的证据提示,树鼩属灵长类近缘的一种小型动物,具有较为发达的神经系统和与人类相似的应激系统,因而可能成为创制精神疾病行为模型的较佳选择。已有的研究表明,树鼩社会挫败模型可能具有比啮齿类更好的表面效度、预测效度及结构效度。由于树鼩与人类的近缘关系,对其抑郁行为的脑机制研究或药物评价可能更具潜在价值。但是,该模型仍有待进一步利用、拓展和完善。
창제이상적동물모형시돌파억욱증연구적기술난점지일。래자진화연구적증거제시,수구속령장류근연적일충소형동물,구유교위발체적신경계통화여인류상사적응격계통,인이가능성위창제정신질병행위모형적교가선택。이유적연구표명,수구사회좌패모형가능구유비교치류경호적표면효도、예측효도급결구효도。유우수구여인류적근연관계,대기억욱행위적뇌궤제연구혹약물평개가능경구잠재개치。단시,해모형잉유대진일보이용、탁전화완선。
Appropriate animal models are essential for elucidating the etiology and pathophysiology of depression. While rodent models are commonly used, the tree shrew shows promise for modeling depression Studies of tree shrews demonstrate an evolutionary relationship to primates, a highly developed nervous system and a more similar stress system to human. Well-accepted etiological stimuli of human depression, for example, social defeat, induce depression-like behaviors in tree shrews; such behaviors can be partially improved by classic antidepressants. This article reviews the social defeat paradigm in the tree threw as a model of depression from perspectives of face, predictive, and construct validities. Underscored by a phylogenetic relationship to humans, tree shrew models of depression may provide a more clinically-relevant approach for studying the neuro-mechanisms of depression and screening antidepressants Nonetheless, the current tree shrew depression model requires further exploration and improvement.