石家庄学院学报
石傢莊學院學報
석가장학원학보
Journal of Shijiazhuang University
2012年
6期
26~29
,共null页
岳红坤 王景翔 周冉 关倩
嶽紅坤 王景翔 週冉 關倩
악홍곤 왕경상 주염 관천
黄芩苷 缓释胶囊 体外释放度
黃芩苷 緩釋膠囊 體外釋放度
황금감 완석효낭 체외석방도
baicalin; sustained-release capsule; release in vitro
制备黄芩苷缓释胶囊,并通过体外释放度对其处方进行优化.以黄芩苷为原料药,羟丙甲纤维素（HPMC）、微晶纤维素（MCC）、乳糖、聚维酮（PVP）的乙醇溶液为辅料制备缓释胶囊,考察不同因素对释放度的影响,通过正交试验优化制备处方.优化后的黄芩苷缓释胶囊的处方为黄芩苷0.5 g,HPMC 0.25 g,MCC 0.2 g,PVP的乙醇溶液浓度为6%,乳糖0.25 g.研究方法简便、快速,体外释放度显示黄芩苷缓释胶囊处方设计比较合理,可进一步研发.
製備黃芩苷緩釋膠囊,併通過體外釋放度對其處方進行優化.以黃芩苷為原料藥,羥丙甲纖維素（HPMC）、微晶纖維素（MCC）、乳糖、聚維酮（PVP）的乙醇溶液為輔料製備緩釋膠囊,攷察不同因素對釋放度的影響,通過正交試驗優化製備處方.優化後的黃芩苷緩釋膠囊的處方為黃芩苷0.5 g,HPMC 0.25 g,MCC 0.2 g,PVP的乙醇溶液濃度為6%,乳糖0.25 g.研究方法簡便、快速,體外釋放度顯示黃芩苷緩釋膠囊處方設計比較閤理,可進一步研髮.
제비황금감완석효낭,병통과체외석방도대기처방진행우화.이황금감위원료약,간병갑섬유소（HPMC）、미정섬유소（MCC）、유당、취유동（PVP）적을순용액위보료제비완석효낭,고찰불동인소대석방도적영향,통과정교시험우화제비처방.우화후적황금감완석효낭적처방위황금감0.5 g,HPMC 0.25 g,MCC 0.2 g,PVP적을순용액농도위6%,유당0.25 g.연구방법간편、쾌속,체외석방도현시황금감완석효낭처방설계비교합리,가진일보연발.
The prescription is optimized through evaluating the release in vitro to prepare sustained-release baicalin capsules. With baicalin for apis, hydroxyl armour cellulose （HPMC）, microcrystalline cellulose （MCC）, lactose, PVP ethanol solution concentration to prepare the sustained-release capsules,influence on each different factor is investigated. Using the rthogonal test method,the optimization of prescription is completed. The optimized baicalin sustained-release capsule prescription is presented ： HPMC 0.25 g,baicalin 0.5 g, MCC 0.2 g, PVP ethanol solution concentration 6% ,lactose 0.25 g. This research method is simple and rapid ;the in-vitro release of baicalin also shows good rationality of the prescription design, and it can be further developed.
