CAJ | 학술논문

研究香菇多糖冻干粉针剂的处方及制备工艺，并对其进行质量评价．经预实验选定复合赋形剂及配比，实验考察其用量对制剂成型性的影响，用正交法筛选最优处方，以冷冻干燥法制备粉针剂，并测定其有关质量指标．通过筛选的优化处方为：香菇多糖50mg，赋形剂L-精氨酸300mg和甘露醇250mg，加水量为75mL，溶液PH值为7．0-7．5；制备的冻干粉针剂质量优良、综合评定其分值为5．处方合理，制备工艺可行，检验结果准确可靠．
연구향고다당동간분침제적처방급제비공예，병대기진행질량평개．경예실험선정복합부형제급배비，실험고찰기용량대제제성형성적영향，용정교법사선최우처방，이냉동간조법제비분침제，병측정기유관질량지표．통과사선적우화처방위：향고다당50mg，부형제L-정안산300mg화감로순250mg，가수량위75mL，용액PH치위7．0-7．5；제비적동간분침제질량우량、종합평정기분치위5．처방합리，제비공예가행，검험결과준학가고．
The formula and preparation technology of Lentinan for treeze-dried powder rejection was investigated, and its quality was evaluated. With the investigation of differem kinds of exeipients and influenee of different dosage on preparation formability, the best formula was selected by orthogonal test. And powder injection was prepared by the technology of freeze-drying and relevant quality indicators were determined. The prepared freeze-dried powder injection was in good quality with comprehensive evaluation score of 5 by the optimized formula：Lentinan （50 mg）, excipients L- arginine （300 mg） and mannitol （250 mg） with adding water to 75 ml and solution PH value of 7.0-7.5. The formula is reasonable with feasible preparation technique, and the test results are accurate and reliable.