CAJ | 학술논문

目的：探讨太极拳运动诱导外周血白细胞Thl／Th2型细胞因子mRNA表达情况，以进一步了解太极拳运动对Thl／Th2型细胞因子平衡的影响，探讨太极拳健身的可能免疫学机制。方法：在健康中老年女性学练太极拳前、练习3月和6月时对其外周血白细胞自发性Thl／／Th2型细胞因子mRNA表达进行实时定量观测。结果：经过太极拳运动干预，中老年妇女外周血白细胞INF-1mRNA的表达量逐渐降低，3、6月时表达量均与干预前相比存在明显差异；IL-4mRNA表达量先降低后回升，但仍未达初始水平，且3月时的表达量与干预前相比存在显著性差异；INF-1mRNA与IL-4mRNA比值逐渐降低，与干预6月相比干预前和干预3月均存在明显差异。结论：太极拳运动使健康中老年妇女Thl／Th2平衡向Th2极化，提示太极拳运动调节机体Thl／Th2型细胞因子的平衡也许是太极拳调节中老年机体免疫力、增强健身效果的可能机制。
목적：탐토태겁권운동유도외주혈백세포Thl／Th2형세포인자mRNA표체정황，이진일보료해태겁권운동대Thl／Th2형세포인자평형적영향，탐토태겁권건신적가능면역학궤제。방법：재건강중노년녀성학련태겁권전、연습3월화6월시대기외주혈백세포자발성Thl／／Th2형세포인자mRNA표체진행실시정량관측。결과：경과태겁권운동간예，중노년부녀외주혈백세포INF-1mRNA적표체량축점강저，3、6월시표체량균여간예전상비존재명현차이；IL-4mRNA표체량선강저후회승，단잉미체초시수평，차3월시적표체량여간예전상비존재현저성차이；INF-1mRNA여IL-4mRNA비치축점강저，여간예6월상비간예전화간예3월균존재명현차이。결론：태겁권운동사건강중노년부녀Thl／Th2평형향Th2겁화，제시태겁권운동조절궤체Thl／Th2형세포인자적평형야허시태겁권조절중노년궤체면역력、증강건신효과적가능궤제。
Objective： To study whether Tai -chi can effectively induce the expression of Thl/Th2 type cytokine messenger RNA （mRNA） in white blood cell. Methods ： Twenty - one community - dwelling middle - aged and old women participated in an intervention program of supervised 48 - style Tai -chi for lh per time, 3 times per week for 24 weeks. Thl/Th2 type cytokine mRNA ex- pression of white blood cell was detected by reverse transcription - polymerase chain reaction （ RT - PCR） before intervention, at 12 wk and 24 wk of training. Results：（1） The expression of INF-~ mRNA both decreased at 12 wk （P 〈 0.05 ） and 24wk （P 〈 0.05 ） compared with that of before in- tervention respectively. （2） The expression of IL- 4 mRNA decreased at 12wk and then increased at 24wk,and there are significant differences only when between 12 wk and before intervention. （3） The ratio of INF - r mRNA and IL - 4 mRNA decreased gradually after Tai - ehi intervention, andthere are significant differences both before intervention and at 12 wk compared with at 24wk. Con- clusion ： The Th2 cytokine in white blood cell increased and predominated after Tai - chi intervention and it suggests that Thl/Th2 cell balance has important implications for the health mechanism of Tai - chi exercise for middle - aged and old women.