CAJ | 학술논문

孕期使用毒品可影响胎儿大脑的正常发育，导致脑内神经递质系统异常以及行为的改变。近年来不断有研究证据提示，胚胎期接触可卡因、吗啡等成瘾药物，可以影响神经细胞的增殖、迁移或凋亡等发育过程，使中脑皮层边缘系统中多巴胺、GABA、谷氨酸等神经元形态、受体功能以及突触可塑性发生改变，从而导致子代的学习记忆和成瘾易感性等行为异常。本文将从行为、神经发育、递质系统以及脑功能等层面归纳胚胎期用药对成瘾相关行为影响机制的重要研究进展，并试图提出可能的研究展望。
잉기사용독품가영향태인대뇌적정상발육，도치뇌내신경체질계통이상이급행위적개변。근년래불단유연구증거제시，배태기접촉가잡인、마배등성은약물，가이영향신경세포적증식、천이혹조망등발육과정，사중뇌피층변연계통중다파알、GABA、곡안산등신경원형태、수체공능이급돌촉가소성발생개변，종이도치자대적학습기억화성은역감성등행위이상。본문장종행위、신경발육、체질계통이급뇌공능등층면귀납배태기용약대성은상관행위영향궤제적중요연구진전，병시도제출가능적연구전망。
Prenatal exposure to addictive drugs can influence the development of fetal brain, leading to abnormality of the main neurotransmitter system and behavioral malfunction. Recent studies showed that prenatal exposure to cocaine or morphine affects the proliferation, migration and apoptosis of neural progenitor, resulting in changes of neuronal morphology, receptor function and synaptic plasticity. Such changes are widely found in dopamine, GABA and glutamate system in mesocorticolimbic system, which leads to behavioral deficits in learning and memory and altered susceptibility to addictive drugs. Here we summarize related studies on behaviors, neural development, neurotransmitter system and brain function and try to put forward further research prospects.