CAJ | 학술논문

探讨4周跑转轮运动与3周限制性应激对成年小鼠海马神经发生和焦虑样行为的影响，旷场实验测试小鼠的焦虑行为，Brdu免疫组织化学法确定新生神经元数量。结果：应激一运动组小鼠体重极显著下降，每日平均运动距离在第1周、第2周较运动组显著减少。运动组和应激一运动组在旷场实验中央区域活动时间、中央与外周区域活动距离比率、中央与外周区域总穿越次数、中央区域总活动距离分别较对照组出现显著或极显著差异。运动组BrdU＋细胞数量较对照组明显增加。运动增强了成年海马神经发生，减少了焦虑行为。应激减少了运动距离，抑制了运动依赖的成年海马神经发生，但是对运动的抗焦虑作用没有明显影响。
탐토4주포전륜운동여3주한제성응격대성년소서해마신경발생화초필양행위적영향，광장실험측시소서적초필행위，Brdu면역조직화학법학정신생신경원수량。결과：응격일운동조소서체중겁현저하강，매일평균운동거리재제1주、제2주교운동조현저감소。운동조화응격일운동조재광장실험중앙구역활동시간、중앙여외주구역활동거리비솔、중앙여외주구역총천월차수、중앙구역총활동거리분별교대조조출현현저혹겁현저차이。운동조BrdU＋세포수량교대조조명현증가。운동증강료성년해마신경발생，감소료초필행위。응격감소료운동거리，억제료운동의뢰적성년해마신경발생，단시대운동적항초필작용몰유명현영향。
To investigate the effects of 4 weeks wheel running and 3 weeks restraint stress on hippocampal neurogenesis and anxiety -like behavior in adult mice. Mice were used to do the open - field test. Number of new neurons was counted by BrdU immunohistochemistry. Weight of stress - exercise mice was very significantly reduced. Compared to the exercise, the average running distance of the stress - exercise mice was significantly down - regulated during the first and second week. Compared to the control group, exercise and stress - exercise mice were significantly different in the time in the center, distance travelled in the periphery, the number the ratio of distance travelled in the center to travelled in the center to distance travelled in the periphery, and the distance travelled in the center, respectively. Only runners showed significantly more BrdU ＋ cells. Thus, running promotes adult hippocampal neurogenesis and alleviates anxiety-like behavior. Stress reduces the running distance as well as inhibits exercise - induced neurogenesis, and has no effect on the anxiolytic action of exercise.