CAJ | 학술논문

植物响应金属的miRNAs的大部分靶标是转录因子。对不同植物中响应金属毒性的miRNAs的研究表明miR319，miR390，miR393和miR398具有重要的调控作用。miR319的靶标是涉及生长控制的TCP转录因子。miR390通过反式作用于siRNAs的生物发生从而发挥它的作用，转而调控生长素响应因子。miR393靶向生长素受体TIRl／AFBs和bHLH转录因子。越来越多的证据表明miR398及其靶标Cu／Zn超氧化物歧化酶在控制暴露于高铜或铁后产生的氧化胁迫方面具有关键作用。该文综述了鉴定与金属毒性响应相关的miRNA以及据其靶标推测它们的潜在作用的新进展。
식물향응금속적miRNAs적대부분파표시전록인자。대불동식물중향응금속독성적miRNAs적연구표명miR319，miR390，miR393화miR398구유중요적조공작용。miR319적파표시섭급생장공제적TCP전록인자。miR390통과반식작용우siRNAs적생물발생종이발휘타적작용，전이조공생장소향응인자。miR393파향생장소수체TIRl／AFBs화bHLH전록인자。월래월다적증거표명miR398급기파표Cu／Zn초양화물기화매재공제폭로우고동혹철후산생적양화협박방면구유관건작용。해문종술료감정여금속독성향응상관적miRNA이급거기파표추측타문적잠재작용적신진전。
Most of the targets for plant metal-responsive miRNAs are transcription factors. Information about metal-responsive miRNAs in different plants points to important regulatory roles of miR319, miR390, miR393, and miR398. The target of miR319 is the TCP transcription factor, implicated in growth control, miR390 exerts its action through the biogenesis of trans- acting small interference RNAs that, in turn, regulate auxin responsive factors, miR393 targets the auxin receptors TIR1/AF- Bs and a bHLH transcription factor. Increasing evidence points to the crucial role of miR398 and its targets Cu/Zn superoxide dismu＇tases in the control of the oxidative stress generated after high copper or iron exposure. The novel advances in identifying miRNAs related to metal toxicity responses and their potential role according to their targets are reviewed.