CAJ | 학술논문

目的：探讨特异针刺和非甾体抗炎药两种治疗方法对兔急性骨骼肌损伤后疼痛的影响。方法：采用随机对照原则，将急性骨骼肌损伤造模成功的24只新西兰白兔分成4组：针刺组、给药组、针刺＋给药组和对照组。用酶联免疫法测不同时刻（损伤前、损伤后即刻、损伤后第1、2、3、6天）兔血清前列腺素E2（PGE2）的浓度来检验不同治疗方法对兔急性骨骼肌损伤疼痛的影响。结果：与对照组相比，在损伤后第一天三个治疗组血清PGE，值均显著性的降低（P〈0．05）；针刺＋给药组有非常显著性效果（P〈0．01），三种疗法相互间比较无显著性差异（P〉0．05）。在损伤后第二天，各组血清PGE2显著性降低（P〈0．05）；非甾体抗炎药组和针刺＋给药组血清PGE2与对照组有非常显著性的差异（P〈0．01）；三种疗法比较无显著性差异（P〉0．05）。在损伤后第三天特异针刺治疗组血清PGE2的值与对照组比无明显差异（P〉0．05），非甾体抗炎药治疗组和针刺＋给药组血清PGE2的值与对照组相比有显著性差异（P〈0．05）；三种疗法相互比较无显著性差异（P〉0．05）。结论：特异针刺和非甾体抗炎药均可降低兔急性骨骼肌损伤后的疼痛程度，两者具有相同疗效；两种疗法联合应用有优于两种疗法单用的趋势。
목적：탐토특이침자화비치체항염약량충치료방법대토급성골격기손상후동통적영향。방법：채용수궤대조원칙，장급성골격기손상조모성공적24지신서란백토분성4조：침자조、급약조、침자＋급약조화대조조。용매련면역법측불동시각（손상전、손상후즉각、손상후제1、2、3、6천）토혈청전렬선소E2（PGE2）적농도래검험불동치료방법대토급성골격기손상동통적영향。결과：여대조조상비，재손상후제일천삼개치료조혈청PGE，치균현저성적강저（P〈0．05）；침자＋급약조유비상현저성효과（P〈0．01），삼충요법상호간비교무현저성차이（P〉0．05）。재손상후제이천，각조혈청PGE2현저성강저（P〈0．05）；비치체항염약조화침자＋급약조혈청PGE2여대조조유비상현저성적차이（P〈0．01）；삼충요법비교무현저성차이（P〉0．05）。재손상후제삼천특이침자치료조혈청PGE2적치여대조조비무명현차이（P〉0．05），비치체항염약치료조화침자＋급약조혈청PGE2적치여대조조상비유현저성차이（P〈0．05）；삼충요법상호비교무현저성차이（P〉0．05）。결론：특이침자화비치체항염약균가강저토급성골격기손상후적동통정도，량자구유상동료효；량충요법연합응용유우우량충요법단용적추세。
Objective： Special acupuncture therapies and / or NSAIDs were used on rabbits suffering from acute skeleton muscle injury, to verify which treatment is better in relieving the pain in acute skeletal muscle injury. Methods ： 24 New Zealand white rabbits suffering from acute skeleton muscle injury are randomly divided into 4 groups, 6 in each group. A ： acupuncture group , B ： drug group, C： acupuncture ＋ drug group, D： control group. Collect arterial blood sample before feeding them in the morning, to detect the concentration of PGE2 in serum of rabbits by enzyme - linked immu-nosorbent assay at different times （before the injury, immediately after injury, the 1,2,3,6 days af-ter injury） to verify which treatment is better to induce the pain in acute skeletal muscle injury. Re-sults ： Compared with the control group, in the first day after injury, the concentration of PGE： in se-rum of three treatment groups decreased （ P 〈 0.05 ）, decreased significantly in the acupuncture ＋ drug group （ P 〈 0.01 ）, but no significant difference among the three groups （ P 〉 0.05 ） ; In the sec-ond day, the concentration of PGE2 in serum of three treatment groups decreased （ P 〈 0.05 ）, there being significant difference between the drug group and acupuncture ＋ drug group （P 〈 0.0! ）, but no significant difference among the three groups（ P 〉 0.05 ） ; In the third day, the concentration of PGE2 in serum of the drug group and acupuncture ＋ drug group decreased （ P 〈 0.05 ） , no signifi-cant change in acupuncture group （ P 〉 0.05 ） ; but no significant difference among the three groups （ P 〉 0.05 ） ; the sixth day, the concentration of PGE2 inserum of groups are not significantly different （ P 〉 0. 05 ）. Conclusions ： The special acupuncture therapy and the NSAIDs therapy may relieve the pain in rabbits suffering from acute skeleton muscle injury, and combination of two methods ends to be better than using only one.