CAJ | 학술논문

金针菇多糖具有抗疲劳、抗肿瘤、提高机体免疫力的作用。使用9周递增负荷跑台训练大鼠运动模型，分为空白对照组，运动对照组，金针菇组。运动1周、3周、9周、10周后取血，测全血白细胞（WBC），血红蛋白（Hb），收集血清检测肌酸激酶（CK）、尿素氮（BUN）、睾酮（T）等，应用实时荧光定量PCR检测Th1、Th2转录因子T-bet和GATA-3的mRNA表达量。结果表明：金针菇能显著提高运动疲劳大鼠WBC、Hb和T，降低CK和BUN，帮助疲劳消除，促进机能恢复，具有良好的免疫调节作用。金针菇具有较好的维持T—bet和GATA-3mRNA的接近正常水平的作用，对于维持T淋巴细胞免疫平衡具有重要作用.
금침고다당구유항피로、항종류、제고궤체면역력적작용。사용9주체증부하포태훈련대서운동모형，분위공백대조조，운동대조조，금침고조。운동1주、3주、9주、10주후취혈，측전혈백세포（WBC），혈홍단백（Hb），수집혈청검측기산격매（CK）、뇨소담（BUN）、고동（T）등，응용실시형광정량PCR검측Th1、Th2전록인자T-bet화GATA-3적mRNA표체량。결과표명：금침고능현저제고운동피로대서WBC、Hb화T，강저CK화BUN，방조피로소제，촉진궤능회복，구유량호적면역조절작용。금침고구유교호적유지T—bet화GATA-3mRNA적접근정상수평적작용，대우유지T림파세포면역평형구유중요작용.
Flammuliua velutipes polysaccharides have the role of anti -fatigue, anti -tumor, enhancing the body immunity. This study uses 9 weeks treadmill training excessive exercise ratas model, which were divided into control group, movement control group, flammulina velutipes ＋ exercise group group. The blood was collected after 1 week,3 weeks, 9 weeks, 10 weeks, measured wilole blood leukoeytes （ WBC ） , hemoglobin （Hb） , collecting serum to measure creatine kinase （CK） , blood urea nitrogen （BUN） and testosterone （T）. Real - time quantitative PCR is used to measure the mRNA expression of Th1, Th2 transcription factor T - bet and GATA -3. The resuhs show that flammulina velutipes can significantly increased WBC, Hb and T, lower CK and BUN, help eliminate fatigue, promote functional recovery and has a good role in immune regulation. Flammulina velutipes has an important role in maintaining T - bet mRNA, GATA -3 mRNA close to normal levels and sustaine T lymphocyte immune in balance .