山东体育学院学报
山東體育學院學報
산동체육학원학보
Journal of Shandong Institute Of Physical Education And Sports
2013年
5期
47~51
,共null页
2型糖尿病 有氧运动 主动脉 胶原代谢
2型糖尿病 有氧運動 主動脈 膠原代謝
2형당뇨병 유양운동 주동맥 효원대사
type 2 diabetes ; aerobic exercise ; artery ; collagen metabolism
目的:探讨长期有氧运动对糖尿病大鼠主动脉晚期糖基化终产物形成及其与胶原代谢的关系.方法:通过高脂喂养加腹腔注射小剂量链脲佐菌素(STZ)构建2型糖尿病SD大鼠模型.将SD大鼠分为正常对照组(C)、糖尿病模型组(D)和糖尿病运动组(DE).糖尿病运动组(DE)大鼠进行不负重游泳运动12周.实验结束后检测大鼠血液GLU、GHb、GSP、Insulin、TG、TC、HDL-C、LDL-C和主动脉AGEs、Hyp、SOD、MDA及Col Ⅰ、Col Ⅳ、FN表达的变化,并对实验结果进行统计分析.结果:与正常对照组(C)相比,糖尿病模型组(D)的血液GLU、GHb、GSP、Insulin、TG、TC、LDL-C水平显著升高(P<0.05或P<0.01),主动脉AGEs、Hyp、MDA含量和Col I、Col Ⅳ、FN表达水平均显著升高(P<0.01),血液HDL-C和主动脉SOD水平显著降低(P<0.01);与糖尿病模型组(D)相比,糖尿病运动组(DE)的血液GLU、GHb、GSP、TG、TC、LDL-C水平显著降低(P<0.01),主动脉AGEs、Hyp、MDA含量和Col Ⅰ、Col Ⅳ、FN表达显著降低(P<0.01),SOD显著升高(P<0.01).结论:长期有氧运动可改善2型糖尿病大鼠主动脉间质胶原沉积的现象,这可能与运动降低血糖、主动脉AGEs含量和氧化应激水平有关.
目的:探討長期有氧運動對糖尿病大鼠主動脈晚期糖基化終產物形成及其與膠原代謝的關繫.方法:通過高脂餵養加腹腔註射小劑量鏈脲佐菌素(STZ)構建2型糖尿病SD大鼠模型.將SD大鼠分為正常對照組(C)、糖尿病模型組(D)和糖尿病運動組(DE).糖尿病運動組(DE)大鼠進行不負重遊泳運動12週.實驗結束後檢測大鼠血液GLU、GHb、GSP、Insulin、TG、TC、HDL-C、LDL-C和主動脈AGEs、Hyp、SOD、MDA及Col Ⅰ、Col Ⅳ、FN錶達的變化,併對實驗結果進行統計分析.結果:與正常對照組(C)相比,糖尿病模型組(D)的血液GLU、GHb、GSP、Insulin、TG、TC、LDL-C水平顯著升高(P<0.05或P<0.01),主動脈AGEs、Hyp、MDA含量和Col I、Col Ⅳ、FN錶達水平均顯著升高(P<0.01),血液HDL-C和主動脈SOD水平顯著降低(P<0.01);與糖尿病模型組(D)相比,糖尿病運動組(DE)的血液GLU、GHb、GSP、TG、TC、LDL-C水平顯著降低(P<0.01),主動脈AGEs、Hyp、MDA含量和Col Ⅰ、Col Ⅳ、FN錶達顯著降低(P<0.01),SOD顯著升高(P<0.01).結論:長期有氧運動可改善2型糖尿病大鼠主動脈間質膠原沉積的現象,這可能與運動降低血糖、主動脈AGEs含量和氧化應激水平有關.
목적:탐토장기유양운동대당뇨병대서주동맥만기당기화종산물형성급기여효원대사적관계.방법:통과고지위양가복강주사소제량련뇨좌균소(STZ)구건2형당뇨병SD대서모형.장SD대서분위정상대조조(C)、당뇨병모형조(D)화당뇨병운동조(DE).당뇨병운동조(DE)대서진행불부중유영운동12주.실험결속후검측대서혈액GLU、GHb、GSP、Insulin、TG、TC、HDL-C、LDL-C화주동맥AGEs、Hyp、SOD、MDA급Col Ⅰ、Col Ⅳ、FN표체적변화,병대실험결과진행통계분석.결과:여정상대조조(C)상비,당뇨병모형조(D)적혈액GLU、GHb、GSP、Insulin、TG、TC、LDL-C수평현저승고(P<0.05혹P<0.01),주동맥AGEs、Hyp、MDA함량화Col I、Col Ⅳ、FN표체수평균현저승고(P<0.01),혈액HDL-C화주동맥SOD수평현저강저(P<0.01);여당뇨병모형조(D)상비,당뇨병운동조(DE)적혈액GLU、GHb、GSP、TG、TC、LDL-C수평현저강저(P<0.01),주동맥AGEs、Hyp、MDA함량화Col Ⅰ、Col Ⅳ、FN표체현저강저(P<0.01),SOD현저승고(P<0.01).결론:장기유양운동가개선2형당뇨병대서주동맥간질효원침적적현상,저가능여운동강저혈당、주동맥AGEs함량화양화응격수평유관.
In order to investigate the impact and metabohsm oi exercise on collagen deposition in artery of diabetic rats, the authors established the model for type 2 diabetes by high - fat diet - fed and low - dose streptozotocin - treated. The diabetic rats were randomly divided into type 2 diabetes control group (D) , type 2 diabetes exercise group (DE) , and normal control group (C). The DE group swam without load for 12 weeks. At the end of the experiment, the levels of GLU, GHb, GSP, Insulin, TG, TC, HDL - C, LDL - C in blood and the levels of AGEs, Hyp, SOD, MDA, Col I,Col IV, FN in artery were tested. The experimental results revealed the following findings: The levels of blood GLU, GHb, GSP, Insulin, TG, TC, LDL - C and artery AGEs, Hyp, Col l, Col IV, FN, oxidative stress were significantly higher( P 〈 0.05 or P 〈 0.01 ) while SOD, HDL - C were significantly lower in group D than those in group C (P 〈0.01 ) ; The levels of blood GLU, GHb, GSP, TG, TC, LDL- C and artery AGEs, Hyp, Col I, Col IV, FN, oxidative stress were significantly lower in group DE than those in group D ( P 〈 0.01 ). The results indicate that exercise can improve arterial collagen deposition of type 2 diabetic rats, which may be related with the reduction of blood GLU and arterial AGEs, oxidative stress of type 2 diabetic rats.