CAJ | 학술논문

新颖寻求特质是个体对新颖刺激或潜在的奖赏线索表现出愉悦或兴奋的先天倾向，并且这种先天倾向会导致个体为寻求潜在的奖赏进行频繁的探索性活动。众多研究表明，新颖寻求水平高的个体药物成瘾易感性高。多巴胺、5-羟色胺、谷氨酸、γ-氨基丁酸、胆囊收缩素、成纤维细胞生长因子及皮质酮可能参与了新颖寻求特质影响药物成瘾易感性的过程。未来，仍需对新颖寻求特质影响药物成瘾易感性的神经生物学机制进行深入研究。
신영심구특질시개체대신영자격혹잠재적장상선색표현출유열혹흥강적선천경향，병차저충선천경향회도치개체위심구잠재적장상진행빈번적탐색성활동。음다연구표명，신영심구수평고적개체약물성은역감성고。다파알、5-간색알、곡안산、γ-안기정산、담낭수축소、성섬유세포생장인자급피질동가능삼여료신영심구특질영향약물성은역감성적과정。미래，잉수대신영심구특질영향약물성은역감성적신경생물학궤제진행심입연구。
Novelty seeking behavioral trait refers to a heritable tendency toward intense exhilaration or excitement when responding to novel stimuli or cues of potential reward, which results in frequent exploratory activity in pursuing potential reward. Extensive studies indicate that high level of novelty seeking behavioral trait is associated with increased susceptibility to drug addiction. Dopamine, serotonin, glutamic acid,γ-aminobutyric acid, eholecystokinin, fibroblast growth factor and corticosterone may be involved in the effect of novelty seeking behavioral trait on susceptibility to drug addiction. In the future, further studies will be focused on neurobiological mechanisms underlying the effect of novelty seeking behavioral trait on susceptibility to drug addiction.