CAJ | 학술논문

HPA轴（下丘脑-垂体-肾上腺皮质轴，hypothalamic—pituitary—adrenal cortex axis）是人类重要的应激内分泌轴，静息与应激条件下HPA轴的机能障碍能引发应激相关疾病，而HPA轴机能障碍的表现和原因并不明确。皮质醇作为HPA轴的终端产物能直接反映HPA轴活动，唾液皮质醇优于其他生物样本皮质醇的特性使其成为测量HPA轴活动的最优指标，因此寻找到合适的唾液皮质醇标识来反映静息与应激条件下的HPA轴调节变化，能促进理解HPA轴机能障碍与疾病间的神经内分泌通路。近来研究常用的是以皮质醇觉醒反应（cortis01．awakeningresponse，CAR）与特里尔社会应激测试（Triersocialstresstest，TSST）来分别表示静息与应激条件下的HPA轴活动。未来研究将结合应激反应的生理、心理指标，进一步考察HPA轴调节的脑网络，为应激反应提供脑．神经内分泌通路的生物基础。
HPA축（하구뇌-수체-신상선피질축，hypothalamic—pituitary—adrenal cortex axis）시인류중요적응격내분비축，정식여응격조건하HPA축적궤능장애능인발응격상관질병，이HPA축궤능장애적표현화원인병불명학。피질순작위HPA축적종단산물능직접반영HPA축활동，타액피질순우우기타생물양본피질순적특성사기성위측량HPA축활동적최우지표，인차심조도합괄적타액피질순표식래반영정식여응격조건하적HPA축조절변화，능촉진리해HPA축궤능장애여질병간적신경내분비통로。근래연구상용적시이피질순각성반응（cortis01．awakeningresponse，CAR）여특리이사회응격측시（Triersocialstresstest，TSST）래분별표시정식여응격조건하적HPA축활동。미래연구장결합응격반응적생리、심리지표，진일보고찰HPA축조절적뇌망락，위응격반응제공뇌．신경내분비통로적생물기출。
Hypothalamic-pituitary-adrenocortical （HPA） axis is considered to be a major neuroendocrine system for understading physiological repsonses to stress. Dysfunction of HPA axis under resting and stressful conditions have been associated with stress-related disorders. However, the specific cause and feature of HPA dysfunction remains unclear. Cortisol, an end product of HPA axis, is believed to directly reflect the characteristics of HPA activity, specifically, the salivary cortisol is considered to be an ideal biolgoical sample to index HPA activity. Thus, identifying suitable salivary cortisol markers to reflect HPA regulation under the resting and stressful conditions may help uncover the neuroendocrin basis of stress-related diseases. Recent research has commonly measured cortisol awakening response （CAR） and implemented the Trier Social Stress Test （TSST） procedures. Future research should combine the physiolgoical and psychological indices as well as investigate the brain networks of HPA axis, thus to elucidate the brain-neuroendocrine biological pathways for stress response.