CAJ | 학술논문

众多研究认为，中枢神经系统不能对运动肌产生或维持有效的神经冲动是运动中枢疲劳的原因之一。机体通过易化系统和抑制系统调节初级运动皮层对外周的运动输出，基底神经节在易化系统中占有重要地位。纹状体是基底节接收和整合信息的门户，主要接受来自皮层和丘脑的谷氨酸（Glu）和来自于黑质的多巴胺（DA）能神经元投射，同时受到γ-氨基丁酸（GABA）和胆碱能（Ach）中间神经元的调节，还受腺苷、NO、5羟色胺（5-HT）等神经递质或／和调质的共同调节。诸多信号在纹状体中等棘状神经元（MSNs）经DARPP-32等信号分子整合后，通过纹状体黑质神经元（直接通路）和纹状体苍白球神经元（间接通路）发出投射，最终通过2条通路的平衡完成对运动的精确调控。就国内外关于纹状体的生理功能及运动疲劳时纹状体可能的调控机制作一较为系统的综述，为相关领域研究人员提供参考。
음다연구인위，중추신경계통불능대운동기산생혹유지유효적신경충동시운동중추피로적원인지일。궤체통과역화계통화억제계통조절초급운동피층대외주적운동수출，기저신경절재역화계통중점유중요지위。문상체시기저절접수화정합신식적문호，주요접수래자피층화구뇌적곡안산（Glu）화래자우흑질적다파알（DA）능신경원투사，동시수도γ-안기정산（GABA）화담감능（Ach）중간신경원적조절，환수선감、NO、5간색알（5-HT）등신경체질혹／화조질적공동조절。제다신호재문상체중등극상신경원（MSNs）경DARPP-32등신호분자정합후，통과문상체흑질신경원（직접통로）화문상체창백구신경원（간접통로）발출투사，최종통과2조통로적평형완성대운동적정학조공。취국내외관우문상체적생리공능급운동피로시문상체가능적조공궤제작일교위계통적종술，위상관영역연구인원제공삼고。
Numerous researches consider that central nervous system can＇ t drive motor muscles effectively is one of the reasons of exercise induced fatigue. The organism regulates primary motor cortex through facilitation system and inhibitory system, and the basal ganglia play an important role in the facilitation system. The striatum is the key to receive and integrate information in the basal ganglia, mainly receives glutamatergic neurons projection coming from cerebral cortex and thalamus, it also mainly receives dopaminergic neurons projection which come from substantia nigra, at the same time, the striatum receives regulation of GABAergic and cholinergic interneurons, and it receives co-regulation of neurotransmitters and neuromodulators, such as adenosine, NO and 5-HT and so on. Many signals integrate via DARPP-32 and other signal molecules in striatal medium spiny neurons, afterwards it projects through striatonigral neurons （direct pathway） and striatopallidal neurons （indirect pathway）, and finally it finishes accurately the control of movement via the balance of the two pathways. The article gives a systematic review of the studies progressing on physiological function of striatal and its possible regulation mechanism in exercise-induced central fatigue, in order to provide reference for related researchers.