CAJ | 학술논문

研究目的：以Th1、Th2细胞为指标,观察递增负荷游泳运动过程中免疫平衡的动态变化。研究方法：雄性8周龄SPF级昆明小鼠进行六周的递增负荷游泳训练,每天一次,每周六天。分别在0周、2周、4周和6周取血,流式细胞术直接测定血液Th1、Th2细胞数量。研究结果;六周递增负荷游泳运动过程中Th1细胞数量第2周明显下降,2周、4周呈上升恢复趋势,6周时基本恢复到正常;Th2细胞运动后2周、4周和6周各组均显著上升。提示在六周的运动过程中,小鼠的体液免疫功能呈增强趋势;在六周的运动周期中,各个采样时点Th1/Th2比值都显著下降。研究结论：六周递增负荷游泳运动过程中,Th1细胞数量的下降,同时Th2细胞增多。Th1/Th2平衡向Th2一侧极化,提示免疫平衡向体液免疫侧漂移。
연구목적：이Th1、Th2세포위지표,관찰체증부하유영운동과정중면역평형적동태변화。연구방법：웅성8주령SPF급곤명소서진행륙주적체증부하유영훈련,매천일차,매주륙천。분별재0주、2주、4주화6주취혈,류식세포술직접측정혈액Th1、Th2세포수량。연구결과;륙주체증부하유영운동과정중Th1세포수량제2주명현하강,2주、4주정상승회복추세,6주시기본회복도정상;Th2세포운동후2주、4주화6주각조균현저상승。제시재륙주적운동과정중,소서적체액면역공능정증강추세;재륙주적운동주기중,각개채양시점Th1/Th2비치도현저하강。연구결론：륙주체증부하유영운동과정중,Th1세포수량적하강,동시Th2세포증다。Th1/Th2평형향Th2일측겁화,제시면역평형향체액면역측표이。
Objection： This research is designed to explore the change of immune balance （Th1/Th2）of mice during six weeks incremental load exercise. Method ：64 male 8 -week old SPE grade KM mice are divided randomly into 8 groups. The experi- mental groups conduct incremental swimming exercise, once a day, and six days a week for 6 weeks. The blood is got respec- tively 0 weeks ,2 weeks, 4 weeks and 6 weeks after exercise. Th1, Th2 cells are calculated by flowcytometry. Result：（ 1 ） The amount of Thl cell droped after exercise, most obvious after 2 weeks, and take on recovery trend in the sixth week. （2） The amount of Th2 cell rise obviously after 2, 4 and 6weeks. （ 3 ） The Th1/Th2 of experimental groups rise obviously in comparision with control group. Conclusion： 1. The number of Thl cells declined and Th2 cells Raised in the six -week incremental swimming exercise. Th1/Th2 balance is broken and polarized to Th2. exercise immunity,