CAJ | 학술논문

随着脑成像研究数量的增长，研究者迫切需要一种能够将众多研究进行整合的元分析方法。本文在简单回顾了以往脑成像元分析方法的基础上，介绍了激活似然性评估法（ALE）的操作实施、优势特征、更新完善，以及其发展与应用。该元分析方法将每一个激活的坐标看作一种分布的可能性，通过特定的算法与拟合获得激活似然值，最后，将不同文献汇聚计算而来的ALE值与虚无分布获得的ALE值进行对比，以确定激活的可能性分布。近十年来，激活似然性评估法几经修正，已被广泛运用于各领域元分析的研究中。
수착뇌성상연구수량적증장，연구자박절수요일충능구장음다연구진행정합적원분석방법。본문재간단회고료이왕뇌성상원분석방법적기출상，개소료격활사연성평고법（ALE）적조작실시、우세특정、경신완선，이급기발전여응용。해원분석방법장매일개격활적좌표간작일충분포적가능성，통과특정적산법여의합획득격활사연치，최후，장불동문헌회취계산이래적ALE치여허무분포획득적ALE치진행대비，이학정격활적가능성분포。근십년래，격활사연성평고법궤경수정，이피엄범운용우각영역원분석적연구중。
With the increasing number of neuroimaging studies, researchers urgently need a way to compare and combine data from diverse studies. This article first reviews kinds of meta-analysis methods of brain imaging, and then introduces a coordinate-based technique which is widely used in neuroimaging studies - Activation Likelihood Estimation （ALE）. The ALE meta-analysis involves modeling each activated focus as a possibility distribution rather than a single point, and then assesses the ALE value by empirical estimates. To differentiate true convergence of loci from random clustering, null hypothesis is applied to obtain an ALE null distribution with the same number of foci as in the real analysis. In recent years, with the development of brain imaging component analysis, the ALE meta-analysis also has benefited from it. Activation likelihood estimation has been revisited several times, and approved by most researchers. Two of the most important corrections are multiple comparisons and the change from ＂fixed-effects analysis＂ to ＂random-eflbcts analysis＂. The ALE has several advantages. Firstly, the ability of combining data from diverse studies is essential for building consensus across studies. Secondly, the use of a theoretically significant threshold provides means to defend the results statistically. Finally, it can be automated following extraction of relevant foci from the literature which can maximize the efficiency and objectivity. The ALE meta-analysis has been widely used in the field of functional neuroimaging in past decades. Nevertheless, we still need to realize that no matter how objective the ALE is, it is not the end but a new beginning.