CAJ | 학술논문

记忆巩固需经觉醒状态下的信息编码和睡眠状态下的巩固阶段两个过程。记忆再巩固理论认为记忆巩固是一个需要多次反复巩固的过程,即使已巩固的记忆也会在提取激活后变得不稳定,需经再巩固才能重返稳定状态,此过程需要新的蛋白质的合成。记忆再巩固具有较强的时间特征,发生在记忆巩固之后,依赖于蛋白质降解的去稳定化阶段和依赖于蛋白质合成的记忆再稳定阶段,所持续的时间窗为6 h。不同类型的记忆是否引发记忆再巩固或消退行为,取决于提取试次暴露所持续时间的长短。
기억공고수경각성상태하적신식편마화수면상태하적공고계단량개과정。기억재공고이론인위기억공고시일개수요다차반복공고적과정,즉사이공고적기억야회재제취격활후변득불은정,수경재공고재능중반은정상태,차과정수요신적단백질적합성。기억재공고구유교강적시간특정,발생재기억공고지후,의뢰우단백질강해적거은정화계단화의뢰우단백질합성적기억재은정계단,소지속적시간창위6 h。불동류형적기억시부인발기억재공고혹소퇴행위,취결우제취시차폭로소지속시간적장단。
Memories are consolidated through the information encoding process during waking and the reprocessing consolidation during sleeping. Memory reconsolidation theory claims that memory consolidation process needs to be repeated for many times. More specifically, it states that consolidated memories transiently return to a labile state upon each retrieval process and must be restabilized to persist further through a reconsolidation process involving new protein synthesis. At this labile state, memories are easily amenable to enhancement or disruption. Memory reconsolidation is also a time-dependent process, it occurs after memory consolidation and persists for about 6 hours, including the protein degradation destabilization phase and the protein synthesis stabilization phase. Re-exposure of the retrieval trial can trigger either memory reconsolidation or extinction, which depends on the duration of retrieval stimulus presentation.