体育科学
體育科學
체육과학
China Sport Science
2015年
5期
38~47
,共null页
血脂异常 有氧运动 中老年 载脂蛋白B基因多态性
血脂異常 有氧運動 中老年 載脂蛋白B基因多態性
혈지이상 유양운동 중노년 재지단백B기인다태성
dyslipidemia ; aerobic exercise ; middle-age; a poli poprotein B gene pol ymorphisms
以血脂异常的中、老年人为对象,研究了ApoB基因XbaI和EcoRI多态性对运动调节血脂异常作用的影响。首先,通过运动耐量试验测定血脂异常人群的心脏功能（F.C.）,在此基础上制订调脂运动处方。运动强度为50%F.C.~70%F.C.,每次运动持续时间为30min~60min,观察了实施调脂运动处方后血脂异常人群的血脂改善情况,探讨了与血脂异常有关的ApoB基因多态性对有氧运动调节血脂作用的影响。研究发现,ApoB基因EcoRI与XbaI多态性会影响运动对血脂异常的调节作用,表现在运动干预后血清HDL-C水平变化上的差异。血脂异常人群中,携带EcoRI位点的E2E2基因型和XbaI位点的X1X2基因型者经有氧运动干预后,血清HDL-C水平显著改善;携带E1E1基因型、E1E2基因型与X1X1基因型者经有氧运动干预后,血清HDL-C水平无明显改善。血脂异常人群中,同时携带E2E2基因型与X1X1基因型者,有氧运动干预后血清HDL-C显著改善;但同时携带E1E2基因型与X1X1基因型者,有氧运动干预后血清HDL-C水平无改善。该结果揭示,血脂异常人群ApoB基因EcoRI与XbaI位点基因型的差异将影响有氧运动的调脂效果。
以血脂異常的中、老年人為對象,研究瞭ApoB基因XbaI和EcoRI多態性對運動調節血脂異常作用的影響。首先,通過運動耐量試驗測定血脂異常人群的心髒功能（F.C.）,在此基礎上製訂調脂運動處方。運動彊度為50%F.C.~70%F.C.,每次運動持續時間為30min~60min,觀察瞭實施調脂運動處方後血脂異常人群的血脂改善情況,探討瞭與血脂異常有關的ApoB基因多態性對有氧運動調節血脂作用的影響。研究髮現,ApoB基因EcoRI與XbaI多態性會影響運動對血脂異常的調節作用,錶現在運動榦預後血清HDL-C水平變化上的差異。血脂異常人群中,攜帶EcoRI位點的E2E2基因型和XbaI位點的X1X2基因型者經有氧運動榦預後,血清HDL-C水平顯著改善;攜帶E1E1基因型、E1E2基因型與X1X1基因型者經有氧運動榦預後,血清HDL-C水平無明顯改善。血脂異常人群中,同時攜帶E2E2基因型與X1X1基因型者,有氧運動榦預後血清HDL-C顯著改善;但同時攜帶E1E2基因型與X1X1基因型者,有氧運動榦預後血清HDL-C水平無改善。該結果揭示,血脂異常人群ApoB基因EcoRI與XbaI位點基因型的差異將影響有氧運動的調脂效果。
이혈지이상적중、노년인위대상,연구료ApoB기인XbaI화EcoRI다태성대운동조절혈지이상작용적영향。수선,통과운동내량시험측정혈지이상인군적심장공능（F.C.）,재차기출상제정조지운동처방。운동강도위50%F.C.~70%F.C.,매차운동지속시간위30min~60min,관찰료실시조지운동처방후혈지이상인군적혈지개선정황,탐토료여혈지이상유관적ApoB기인다태성대유양운동조절혈지작용적영향。연구발현,ApoB기인EcoRI여XbaI다태성회영향운동대혈지이상적조절작용,표현재운동간예후혈청HDL-C수평변화상적차이。혈지이상인군중,휴대EcoRI위점적E2E2기인형화XbaI위점적X1X2기인형자경유양운동간예후,혈청HDL-C수평현저개선;휴대E1E1기인형、E1E2기인형여X1X1기인형자경유양운동간예후,혈청HDL-C수평무명현개선。혈지이상인군중,동시휴대E2E2기인형여X1X1기인형자,유양운동간예후혈청HDL-C현저개선;단동시휴대E1E2기인형여X1X1기인형자,유양운동간예후혈청HDL-C수평무개선。해결과게시,혈지이상인군ApoB기인EcoRI여XbaI위점기인형적차이장영향유양운동적조지효과。
This paper studies the effects of EcoRI and XbaI polymorphisms of apolipoprotein B gene on the treatment of dyslipidemia through exercise. The subjects were middle-aged people with dyslipidemia. First of all, the cardiac functional capacity （F. C. ） was measured using gra- ded exercise testing. After that, the exercise prescription was drawn up. The exercise intensity was at the level of 50%-70% F. C. and the duration were 30 to 60 minutes. The improvement in serum lipids profile after applying exercise prescription was observed and the effect of apolipoprotein B gene polymorphism on the treatment of dyslipidemia through exercise inter- ventions was probed into. The results show that EcoRI and XbaI polymorphisms of apolipopro- tein B gene can influence the effect of exercise interventions on dyslipidemia treatment, which mainly appears as the difference in the improvement of serum HDL-C level after exercise inter- ventions. For those individuals with E2 E2 or X1 ？（2 genotypes, their serum HDL-C level im- proved after aerobic exercise interventions. However, there was no change in serum HDL-C level of those individuals with E1 E1 , E1 Fe or X1 X1 genotypes. For those individuals with both Fe E2 and X1 X1 genotypes, aerobic exercise interventions still can improve serum HDL C level. Nevertheless, for those individuals with both E1 E2 and X1 X1 genotypes, aerobic exercise inter- ventions can not make an improvement in serum HDL-C level. These results designate that the differentiations of EcoRI and XbaI polymorphisms of apolipoprotein B will result in different effects of exercise interventions on blood lipids.
