北京体育大学学报
北京體育大學學報
북경체육대학학보
Journal of Beijing University of Physical Education
2015年
6期
55~59
,共null页
中年女性 体力活动 端粒体长度 抗衰老 肥胖
中年女性 體力活動 耑粒體長度 抗衰老 肥胖
중년녀성 체력활동 단립체장도 항쇠로 비반
middle-aged women; physical activity; telomere length; anti-aging; obesity
目的：测量、评价40～59岁女性体力活动（PA）水平,探讨PA水平与人体抗衰老标志——端粒体相对长度（T/S）的相关性。方法：筛选71名40～59岁女性,通过7 d的加速度计佩戴,测试、评价PA水平,并计算出1周从事中等强度PA（MPA）的时间,将其分为PA活跃组和PA不足组。采用实时荧光定量PCR法测人体外周血白细胞T/S值,分析PA水平与T/S值之间的相关性。结果：40～59岁女性有52.11%未达到我国最低体力活动推荐量,即PA不足;在40～49岁、50～59岁年龄组,年龄与T/S值呈负相关（1.80±0.78 vs.1.44±0.65;r=-0.364）;40～49岁、50～59岁MPA的时间与T/S值之间呈正相关（r=0.474 vs.r=0.268）;在同一年龄段,超重肥胖组中年女性的T/S值均明显小于正常体重组的（1.58±0.69 vs.1.77±0.71;1.34±0.60 vs.1.57±0.97）。结论：本研究中,40～59岁女性有52.11%未达到我国最低体力活动推荐量;此推荐量能够延缓40～49岁女性T/S值因增龄引起的下降,对人体抗衰老有积极的促进作用;PA水平达到我国推荐量的50～59岁女性并未显示出T/S值因增龄引起的下降;在同年龄组,超重肥胖组的T/S值相对较小。
目的：測量、評價40～59歲女性體力活動（PA）水平,探討PA水平與人體抗衰老標誌——耑粒體相對長度（T/S）的相關性。方法：篩選71名40～59歲女性,通過7 d的加速度計珮戴,測試、評價PA水平,併計算齣1週從事中等彊度PA（MPA）的時間,將其分為PA活躍組和PA不足組。採用實時熒光定量PCR法測人體外週血白細胞T/S值,分析PA水平與T/S值之間的相關性。結果：40～59歲女性有52.11%未達到我國最低體力活動推薦量,即PA不足;在40～49歲、50～59歲年齡組,年齡與T/S值呈負相關（1.80±0.78 vs.1.44±0.65;r=-0.364）;40～49歲、50～59歲MPA的時間與T/S值之間呈正相關（r=0.474 vs.r=0.268）;在同一年齡段,超重肥胖組中年女性的T/S值均明顯小于正常體重組的（1.58±0.69 vs.1.77±0.71;1.34±0.60 vs.1.57±0.97）。結論：本研究中,40～59歲女性有52.11%未達到我國最低體力活動推薦量;此推薦量能夠延緩40～49歲女性T/S值因增齡引起的下降,對人體抗衰老有積極的促進作用;PA水平達到我國推薦量的50～59歲女性併未顯示齣T/S值因增齡引起的下降;在同年齡組,超重肥胖組的T/S值相對較小。
목적：측량、평개40～59세녀성체력활동（PA）수평,탐토PA수평여인체항쇠로표지——단립체상대장도（T/S）적상관성。방법：사선71명40～59세녀성,통과7 d적가속도계패대,측시、평개PA수평,병계산출1주종사중등강도PA（MPA）적시간,장기분위PA활약조화PA불족조。채용실시형광정량PCR법측인체외주혈백세포T/S치,분석PA수평여T/S치지간적상관성。결과：40～59세녀성유52.11%미체도아국최저체력활동추천량,즉PA불족;재40～49세、50～59세년령조,년령여T/S치정부상관（1.80±0.78 vs.1.44±0.65;r=-0.364）;40～49세、50～59세MPA적시간여T/S치지간정정상관（r=0.474 vs.r=0.268）;재동일년령단,초중비반조중년녀성적T/S치균명현소우정상체중조적（1.58±0.69 vs.1.77±0.71;1.34±0.60 vs.1.57±0.97）。결론：본연구중,40～59세녀성유52.11%미체도아국최저체력활동추천량;차추천량능구연완40～49세녀성T/S치인증령인기적하강,대인체항쇠로유적겁적촉진작용;PA수평체도아국추천량적50～59세녀성병미현시출T/S치인증령인기적하강;재동년령조,초중비반조적T/S치상대교소。
Purpose： The Purpose of this study was to measure and evaluate the physical activities（ PA） of 40- 59 years old women,and detect the relationship between PA level and telomere length which is a body＇s anti-aging maker. Methods： Seventy-one 40- 59 years old women were recruited and required to wear accelerometer for seven days,and then were divided into PA activity group and PA inactivity group. Their PA level was tested,and their moderate-intensity PA（ MPA） per week was calculated. Also their relative length of telomere（ T / S） of blood leukocyte was tested by PCR,and the correlation between T / S and PA was explored. Results： 1） There are52. 11% 40- 59 years old women don＇t have enough PA while 72. 73% obese 40- 59 years old women haven＇t enough PA. 2） There is negative correlation between age and T / S（ r =- 0. 364）. 3） There are positive correlations between MPA and T / S in 40- 49 years old women（ r = 0. 268） and 50- 59 years old women（ r = 0. 474）.4） T / S is shorter in obese women than in normal women（ 1. 42 ± 0. 70 vs. 1. 72 ± 0. 69）. Conclusions： Keeping a high level of PA can delay the shortening of the telomere length caused by aging,which can promote anti-aging of human. The aging degree of overweight and obese middle-aged women is higher than that of normal weight women with the same ages.
