CAJ | 학술논문

目的探讨单纯放射治疗或多西他赛联合萘达铂同期放射治疗局部晚期鼻咽癌的临床效果和不良反应.方法将72例经病理证实的局部晚期鼻咽癌患者完全随机分为单纯放疗组和同期放化组各36例,单纯放疗组患者每周照射5次,每次2 Gy,使鼻咽部平均剂量维持在66～74 Gy/7周,颈部平均剂量维持在50～ 72 Gy/6.5周;同期放化组在单纯放疗的基础上加多西他赛联合萘达铂同期化疗,第1天予多西他赛75 mg/m2静脉滴注,第1～5天予萘达铂20 mg/m2静脉滴注,每3周为1个疗程,共2个疗程.结果 2组患者1年生存率单纯放疗组91.67％、同期放化组100％;治疗后随访3年生存率单纯放疗组69.44％、同期放化组88.9％;3年复发率单纯放疗组8.3％、同期放化组2.8％;远处转移率单纯放疗组8.3％、同期放化组2.8％;不良反应的发生率2组比较,差异无统计学意义(P＞0.05).结论多西他赛联合萘达铂同期放疗治疗局部晚期鼻咽癌的临床疗效优于单纯放疗.
목적 탐토단순방사치료혹다서타새연합내체박동기방사치료국부만기비인암적림상효과화불량반응.방법 장72례경병리증실적국부만기비인암환자완전수궤분위단순방료조화동기방화조각36례,단순방료조환자매주조사5차,매차2 Gy,사비인부평균제량유지재66～74 Gy/7주,경부평균제량유지재50～ 72 Gy/6.5주;동기방화조재단순방료적기출상가다서타새연합내체박동기화료,제1천여다서타새75 mg/m2정맥적주,제1～5천여내체박20 mg/m2정맥적주,매3주위1개료정,공2개료정.결과 2조환자1년생존솔단순방료조91.67％、동기방화조100％;치료후수방3년생존솔단순방료조69.44％、동기방화조88.9％;3년복발솔단순방료조8.3％、동기방화조2.8％;원처전이솔단순방료조8.3％、동기방화조2.8％;불량반응적발생솔2조비교,차이무통계학의의(P＞0.05).결론 다서타새연합내체박동기방료치료국부만기비인암적림상료효우우단순방료.
Objective To investigate docetaxel combined with Nedaplatin and concomitant radiation therapy and two received radiotherapy for locally advanced nasopharyngeal cancer treatment clinical effect and toxicity.Methods Seventy and two patients with locally advanced nasopharyngeal carcinoma patients with pathologically confirmed locally advanced nasopharyngeal carcinoma were randomly assigned radiotherapy alone group 36 cases and the same chemoradiotherapy group of 36 cases.Radiotherapy alone group:Using a continuous exposure,5 times a week,each irradiation 2 Gy,the average dose to the nasopharynx 66 ～ 74 Gy/7 weeks,neck average dose 50 ～ 72 Gy/6.5 weeks.Over the same period chemoradiotherapy group:In the radiotherapy alone group on the basis of his race Jiaduo Xi same chemotherapy combined with Nedaplatin,docetaxel 75 mg/m2,intravenous infusion d1,Nedaplatin 20 mg/m2,intravenous drip d1 ～ 5,every 3 weeks for a course of treatment,a total of 2 courses.Results The patients in the control group during the same period the efficiency of 91.67％,up 100％ of group treatment were followed up for 3-year survival rate in control group 69.44％,up 88.9％ of group.3-year recurrence rate in the control group 8.33％,complications were 2.8％.Conclusions Docetaxel combined with nedaplatin and concomitant radiation therapy in the treatment of locally advanced nasopharyngeal carcinoma effect better than that radiotherapy alone.