CAJ | 학술논문

急性排斥反应是肝移植术后早期严重并发症.许多研究证明T细胞是介导急性排斥反应的主要因素,而体液因素则在慢性排斥反应中起到重要作用.但是,随着临床研究的深入,已有明确的证据表明体液免疫在早期急性排斥反应中也起到重要作用,并带来严重的后果.为此,我们有必要重新认识体液免疫在肝脏移植中的重要作用.本文从抗体参与排斥反应的类型及临床证据、目前体液免疫学说存在的争议和相关治疗方案等多方面对体液免疫在肝脏移植排斥反应中的作用进行综述,以便为临床合理治疗肝脏移植术后排斥反应提供理论依据.
급성배척반응시간이식술후조기엄중병발증.허다연구증명T세포시개도급성배척반응적주요인소,이체액인소칙재만성배척반응중기도중요작용.단시,수착림상연구적심입,이유명학적증거표명체액면역재조기급성배척반응중야기도중요작용,병대래엄중적후과.위차,아문유필요중신인식체액면역재간장이식중적중요작용.본문종항체삼여배척반응적류형급림상증거、목전체액면역학설존재적쟁의화상관치료방안등다방면대체액면역재간장이식배척반응중적작용진행종술,이편위림상합리치료간장이식술후배척반응제공이론의거.
Acute rejection is one of the serious early postoperative complications after liver transplantation.Many studies have shown that acute rejection was mainly mediated by T cells,while humoral factors were responsible for chronic rejection.However,accumulating evidences have demonstrated that humoral immune factors also played an important role in early acute rejection and usually resulted in severe adverse events.Here we clarify the role of humoral immunity in liver transplant rejection,which may help guide the clinical management of such patients with humoral rejection after liver transplantation.