四川医学
四川醫學
사천의학
Sichuan Medical Journal
2015年
8期
1127-1129
,共3页
早产儿%呼吸暂停%咖啡因%维持剂量
早產兒%呼吸暫停%咖啡因%維持劑量
조산인%호흡잠정%가배인%유지제량
premature infants%apnea%caffeine%maintenance dose
目的 探讨不同维持剂量咖啡因治疗早产儿呼吸暂停的疗效. 方法 将我院NICU 2012年1月至2014年11月3年间收治并符合条件的77例出现呼吸暂停的早产儿随机分为3组,A组23例,B组28例,C组26例,三组均在常规治疗(按摩脊背,弹足底,俯卧位,若不能缓解并出现发绀时予以复苏囊正压给氧)的基础上,使用咖啡因治疗,先给予20mg/kg负荷量, 24h后三组分别给予5mg/kg、10mg/kg、15mg/kg维持. 结果 B、C两组发生呼吸暂停的次数明显减少,治疗时间较A组明显缩短,停药时间提前,A、B两组相比,A、C两组相比差异有统计学意义( P<0. 05 ); B、C两组相比差异无统计学意义(P>0. 05). 结论 早产儿呼吸暂停使用咖啡因治疗先用20mg/kg负荷量后,维持量用10mg/kg效果明显.
目的 探討不同維持劑量咖啡因治療早產兒呼吸暫停的療效. 方法 將我院NICU 2012年1月至2014年11月3年間收治併符閤條件的77例齣現呼吸暫停的早產兒隨機分為3組,A組23例,B組28例,C組26例,三組均在常規治療(按摩脊揹,彈足底,俯臥位,若不能緩解併齣現髮紺時予以複囌囊正壓給氧)的基礎上,使用咖啡因治療,先給予20mg/kg負荷量, 24h後三組分彆給予5mg/kg、10mg/kg、15mg/kg維持. 結果 B、C兩組髮生呼吸暫停的次數明顯減少,治療時間較A組明顯縮短,停藥時間提前,A、B兩組相比,A、C兩組相比差異有統計學意義( P<0. 05 ); B、C兩組相比差異無統計學意義(P>0. 05). 結論 早產兒呼吸暫停使用咖啡因治療先用20mg/kg負荷量後,維持量用10mg/kg效果明顯.
목적 탐토불동유지제량가배인치료조산인호흡잠정적료효. 방법 장아원NICU 2012년1월지2014년11월3년간수치병부합조건적77례출현호흡잠정적조산인수궤분위3조,A조23례,B조28례,C조26례,삼조균재상규치료(안마척배,탄족저,부와위,약불능완해병출현발감시여이복소낭정압급양)적기출상,사용가배인치료,선급여20mg/kg부하량, 24h후삼조분별급여5mg/kg、10mg/kg、15mg/kg유지. 결과 B、C량조발생호흡잠정적차수명현감소,치료시간교A조명현축단,정약시간제전,A、B량조상비,A、C량조상비차이유통계학의의( P<0. 05 ); B、C량조상비차이무통계학의의(P>0. 05). 결론 조산인호흡잠정사용가배인치료선용20mg/kg부하량후,유지량용10mg/kg효과명현.
Objective To explore the curative effect of different maintenance dose plus caffeine for the treatment of pre-mature infant apnea. Methods From January 2012 - November 2014 treated 80 cases in NICU with apnea of premature infants were randomly divided into 3 groups, group A (23 cases), group B (28 cases), group C (26 cases), three groups were received routine therapy ( massage back, playing A foot, the prone position, if can't ease and cyanosis when recovery capsule positive pres-sure to oxygen) , on the basis of using caffeine treatment, providing first 20 mg/kg body weight load. 24 hours later the three groups were given 5 mg/kg, 10 mg/kg, and 15 mg/kg. Results The rate of apnea was significantly reduce in group B and C and the treatment time was shortened obviously compared with group A. A, B, compared two groups A and C was statistically significant difference in two groups, P<0. 05;B, C, there was no statistically significant difference in two groups(P>0. 05). Conclusion The premature infant apnea using caffeine after treatment with 20 mg/kg load first, maintain the quantity with 10 mg/kg body weight.
