CAJ | 학술논문

目的分析457例EBV(Epstein-Barr virus infection, EBV)不同感染类型的患者的CVD(Cardiovascular dis-ease, CVD)发病以及与CVD发病相关的炎症因子表达水平,探讨EBV不同感染类型的患者与CVD发生存在的相关性.方法回顾性分析457例EBV的患者( IM、CAEBV, EBV-HLH) CVD发生率,及EBV-DNA、D-Dimer、BNP、 IL-6的峰值表达水平与CVD发生的相关性. 结果 EBV感染不同类型患者CVD的发生率明显不同,其中EBV-HLH最高,IM最低;在IM、CAEBV、EBV-HLH组内CVD发生和未发生组中相关指标BNP、D-Dimer、IL-6 表达差异有统计学意义( P<0. 01 ) ,而CVD发生患者中随着EBV感染发病的严重BNP、D-Dimer、IL-6表达明显增高;EBV感染诱发的CVD患者中BNP表达水平与D-Dimer和IL-6呈正相关,其中D-Dimer与BNP相关性最高. 结论 EBV感染可能继发心血管疾病的风险,且随着EBV感染程度的增加,风险越大;CVD实验室相关检测因子的相关性统计分析发现,EBV感染及感染程度可能通过影响炎症因和血栓形成相关因子的表达水平进而促成心血管疾病的发生.
목적 분석457례EBV(Epstein-Barr virus infection, EBV)불동감염류형적환자적CVD(Cardiovascular dis-ease, CVD)발병이급여CVD발병상관적염증인자표체수평,탐토EBV불동감염류형적환자여CVD발생존재적상관성.방법 회고성분석457례EBV적환자( IM、CAEBV, EBV-HLH) CVD발생솔,급EBV-DNA、D-Dimer、BNP、 IL-6적봉치표체수평여CVD발생적상관성. 결과 EBV감염불동류형환자CVD적발생솔명현불동,기중EBV-HLH최고,IM최저;재IM、CAEBV、EBV-HLH조내CVD발생화미발생조중상관지표BNP、D-Dimer、IL-6 표체차이유통계학의의( P<0. 01 ) ,이CVD발생환자중수착EBV감염발병적엄중BNP、D-Dimer、IL-6표체명현증고;EBV감염유발적CVD환자중BNP표체수평여D-Dimer화IL-6정정상관,기중D-Dimer여BNP상관성최고. 결론 EBV감염가능계발심혈관질병적풍험,차수착EBV감염정도적증가,풍험월대;CVD실험실상관검측인자적상관성통계분석발현,EBV감염급감염정도가능통과영향염증인화혈전형성상관인자적표체수평진이촉성심혈관질병적발생.
Objective To analyze association between CVD ( Cardiovascular diseases) and levels of inflammatory factors in 457 patients of EBV ( Epstein -Barr virus get infection, and EBV) different types of infection. Methods The CVD rate was retrospectively analyzed in and 457 patients with EBV ( IM, CAEBV, EBV - HLH) and the correlation between peak expression levels of EBV DNA, D-Dimer, BNP, IL-6 and the occurrence of CVD. Results The incidence rate of EBV infection in patients with different types of CVD were obviously different, EBV-HLH was highest while IM lowest, CAEBV, EBV in IM-HLH CVD not happening within group BNP, D-Dimer in relevant indicators were differentially expressed, IL-6 (P<0. 01), and CVD in patients with EBV infection incidence of severe BNP, D-Dimer, IL-6 expression increased obviously;EBV infection induced the expression of BNP levels in patients with CVD and D-Dimer and IL-6 were positively correlated, the D-Dimer with highest correlation with the BNP. Conclusion Increased EBV infection could lead to the risk of cardioascular disease, and CVD factors associated laboratory related statistical analysis found that EBV infection, and the degree of infection may be affected by the expression level of inflamma-tion and thrombosis related factors, in turn, contribute to the occurrence of cardiovascular disease.