中国医科大学学报
中國醫科大學學報
중국의과대학학보
Journal of China Medical University
2015年
8期
749-752
,共4页
乙型肝炎%抗病毒治疗%白细胞介素28B%基因多态性%meta分析
乙型肝炎%抗病毒治療%白細胞介素28B%基因多態性%meta分析
을형간염%항병독치료%백세포개소28B%기인다태성%meta분석
hepatitis B%antiviral therapy%IL-28B%gene polymorphism%meta analysis
目的 研究白细胞介素28B( IL-28B)基因多态性与HBeAg阳性的慢性乙型肝炎患者应用干扰素病毒学应答的相关性.方法 计算机检索PubMed、web of Science、China Bio Medicine(CBM)、万方数据库等,由2名评价员独立检索和提取资料并交叉核对,纳入相关病例对照试验.采用Cochrane协作网提供的RevMan 5.3软件进行meta分析,应用Stata11.0软件进行发表偏倚检验.结果 共纳入文献7篇,包括1 345例患者,经过meta分析后发现与rs8099917 TG/GG等位基因相比,rs8099917 TT等位基因对于HBeAg阳性的慢性乙型肝炎患者应用干扰素的病毒学应答无明显差异(P=0.20).rs12979860 CC与CT/TT等位基因相比对于病毒学应答的发生没有差异(P=0.75).结论 IL-28B(rs8099917、rs12979860)的基因多态性与HBeAg阳性慢性乙型肝炎患者应用干扰素达到持续病毒应答无相关性.
目的 研究白細胞介素28B( IL-28B)基因多態性與HBeAg暘性的慢性乙型肝炎患者應用榦擾素病毒學應答的相關性.方法 計算機檢索PubMed、web of Science、China Bio Medicine(CBM)、萬方數據庫等,由2名評價員獨立檢索和提取資料併交扠覈對,納入相關病例對照試驗.採用Cochrane協作網提供的RevMan 5.3軟件進行meta分析,應用Stata11.0軟件進行髮錶偏倚檢驗.結果 共納入文獻7篇,包括1 345例患者,經過meta分析後髮現與rs8099917 TG/GG等位基因相比,rs8099917 TT等位基因對于HBeAg暘性的慢性乙型肝炎患者應用榦擾素的病毒學應答無明顯差異(P=0.20).rs12979860 CC與CT/TT等位基因相比對于病毒學應答的髮生沒有差異(P=0.75).結論 IL-28B(rs8099917、rs12979860)的基因多態性與HBeAg暘性慢性乙型肝炎患者應用榦擾素達到持續病毒應答無相關性.
목적 연구백세포개소28B( IL-28B)기인다태성여HBeAg양성적만성을형간염환자응용간우소병독학응답적상관성.방법 계산궤검색PubMed、web of Science、China Bio Medicine(CBM)、만방수거고등,유2명평개원독립검색화제취자료병교차핵대,납입상관병례대조시험.채용Cochrane협작망제공적RevMan 5.3연건진행meta분석,응용Stata11.0연건진행발표편의검험.결과 공납입문헌7편,포괄1 345례환자,경과meta분석후발현여rs8099917 TG/GG등위기인상비,rs8099917 TT등위기인대우HBeAg양성적만성을형간염환자응용간우소적병독학응답무명현차이(P=0.20).rs12979860 CC여CT/TT등위기인상비대우병독학응답적발생몰유차이(P=0.75).결론 IL-28B(rs8099917、rs12979860)적기인다태성여HBeAg양성만성을형간염환자응용간우소체도지속병독응답무상관성.
Objective To explore the association between the polymorphism in IL-28B gene and the interferon virological response in HBeAg-posi-tive chronic hepatitis B patients. Methods A literature search was performed on PubMed,web of Science,China Bio Medicine(CBM)and wan-Fang database. The references was screened with the inclusion and exclusion criteria,and then data were extracted and methodological quality of the studies was judged. Statistical analysis was carried out with RevMan 5.3 and STATA 11.0. Results Totally 7 publications were recruited for the study,including 1 345 patients. The meta-analysis showed that there was no significant difference of interferon response between HBeAg-positive chronic hepatitis B patients with rs8099917TG/GG alleles and rs8099917TT alleles (P= 0.20). There was no statistical difference between Rs12979860CC and CT/TT allele for the sustained virological response(P=0.75). Conclusion Our current meta-analysis suggests that there was no correlation of rs8099917,rs12979860 polymorphism in IL-28B with the sustained virological response to interferon in HBeAg-positive chronic hepatitis b.
