CAJ | 학술논문

目的通过免疫组化的方法检测Fascin在乳腺癌中的表达情况并分析其与乳腺癌患者预后的关系.方法收集中国医科大学附属第一医院肿瘤外科2007年1月至10月乳腺癌患者110例,采用免疫组化方法检测Fascin的表达情况,并且通过kaplan-meier曲线及cox模型分析Fascin的表达在乳腺癌预后中的意义.结果乳腺癌组织中Fascin蛋白的表达与患者的年龄、肿瘤大小、TNM分期及HER2表达情况无相关性(P>0.05).而与腋窝淋巴结转移及ER(-)、PR(-)有明显的相关性(P<0.05).Fascin阳性的乳腺癌患者无瘤生存时间短于Fascin阴性患者,是影响乳腺癌患者无瘤生存时间的独立危险因素.而与乳腺癌患者的总生存时间无明显关系.结论 Fascin在乳腺癌中高表达与不良预后相关,是影响乳腺癌患者无瘤生存时间的独立危险因素.
목적 통과면역조화적방법검측Fascin재유선암중적표체정황병분석기여유선암환자예후적관계.방법 수집중국의과대학부속제일의원종류외과2007년1월지10월유선암환자110례,채용면역조화방법검측Fascin적표체정황,병차통과kaplan-meier곡선급cox모형분석Fascin적표체재유선암예후중적의의.결과 유선암조직중Fascin단백적표체여환자적년령、종류대소、TNM분기급HER2표체정황무상관성(P>0.05).이여액와림파결전이급ER(-)、PR(-)유명현적상관성(P<0.05).Fascin양성적유선암환자무류생존시간단우Fascin음성환자,시영향유선암환자무류생존시간적독립위험인소.이여유선암환자적총생존시간무명현관계.결론 Fascin재유선암중고표체여불량예후상관,시영향유선암환자무류생존시간적독립위험인소.
Objective To investigate the relationship between the expression of Fascin and breast cancer prognosis. Methods Paraffin sections of breast cancer from 110 patients were investigated by immunohostochemistry with monoclonal anti-fascin antibody. Data of the Fascin expression and clinicopathological variables were analyzed for disease-free survival(DFS)and overall survival(OS)by Kaplan-miere and cox model. Results The expression of Fascin was significantly associated with ER negative,PR negative and lymph node metastasis,but not with age,HER2 status and tumor size. The patients with positive expression of Fascin had shorter disease free survival time than those without Fascin expression. Conclusion High expression of Fascin is associated with poor prognosis in breast cancer. Fascin is an independent prognostic indicator of disease-free survival time.