CAJ | 학술논문

综述近期采用减瘤手术及生物靶向药物治疗转移性肾细胞癌(单发肺转移灶)的文献资料 ,关键词包括 :转移性肾细胞癌(metastatic renal cell carcinoma) ,减瘤性肾切除术(cytoreductive nephrectomy) ,靶向治疗(targeted therapy) ,转移灶切除(metas-tasectomy).现有观点认为 ,对于转移性肾癌 ,尽管手术治疗是姑息性治疗 ,但在过去的几十年 ,减瘤性肾切除术显著提高了部分患者的总生存期.靶向药物的出现改变了转移性肾癌的治疗策略.对肾癌潜在生物学机制的深入研究推动了分子靶向药物的发展 ,与早期的免疫治疗相比 ,它能提高无进展生存期和总生存期 ,并能改善生活质量.临床上对于单发转移灶肾癌的治疗仍存在争议 ,多数认为若患者情况许可 ,可同期进行或分期进行肺转移灶切除.
종술근기채용감류수술급생물파향약물치료전이성신세포암(단발폐전이조)적문헌자료 ,관건사포괄 :전이성신세포암(metastatic renal cell carcinoma) ,감류성신절제술(cytoreductive nephrectomy) ,파향치료(targeted therapy) ,전이조절제(metas-tasectomy).현유관점인위 ,대우전이성신암 ,진관수술치료시고식성치료 ,단재과거적궤십년 ,감류성신절제술현저제고료부분환자적총생존기.파향약물적출현개변료전이성신암적치료책략.대신암잠재생물학궤제적심입연구추동료분자파향약물적발전 ,여조기적면역치료상비 ,타능제고무진전생존기화총생존기 ,병능개선생활질량.림상상대우단발전이조신암적치료잉존재쟁의 ,다수인위약환자정황허가 ,가동기진행혹분기진행폐전이조절제.
To review the recent literature on the treatment strategy for patients with metastatic renal cell carcinoma (mRCC) ,articles in PubMed and Wanfang databases were searched with key words of"metastatic renal cell carcinoma" ,"cy-toreductive nephrectomy" ,"targeted therapy" and "metastasectomy" .Although surgical intervention has been performed in mRCC patients largely as a palliative measure ,over the last decade ,cytoreductive nephrectomy has demonstrated significant improvement in overall survival for appropriately selected patients .The introduction of novel molecular -targeted agents has revolutionised the management of patients with metastatic renal cell carcinoma .The development of new targeted therapy is the result of understanding biological pathways underlying RCC ,and it can increase progression-free and overall survival and improve the quality of life compared with previous toxic immunotherapy .Cytoreductive nephrectomy for patients with simulta-neous complete resection of a single metastasis may improve survival and delay systemic therapy .However ,the therapeutic op-tions for metastatic renal cell carcinoma are still controversial .The article will briefly review and discuss this issue .