CAJ | 학술논문

目的:评估延迟应用重组人促红细胞生成素(rhEPO)治疗大鼠急性挤压性胸脊髓损伤的神经保护作用. 方法:将16只健康成年雄性SD大鼠随机分为对照组( SCI组)和实验组( rhEPO组) , SCI组在脊髓损伤后2 h ,术后第1、3天给予生理盐水治疗,而实验组则在损伤后 2 h ,术后第 1、3天给予 rhEPO (3 000 U/kg)治疗,共观察4 d.主要研究指标有BBB评分、凋亡指数、炎症指数及电镜研究.结果:延迟应用rhEPO可以抑制细胞凋亡,调节炎症反应,改善脊髓损伤的超微结构,改善运动功能. 结论:延迟应用rhEPO治疗大鼠急性脊髓损伤具有神经保护效应.
목적:평고연지응용중조인촉홍세포생성소(rhEPO)치료대서급성제압성흉척수손상적신경보호작용. 방법:장16지건강성년웅성SD대서수궤분위대조조( SCI조)화실험조( rhEPO조) , SCI조재척수손상후2 h ,술후제1、3천급여생리염수치료,이실험조칙재손상후 2 h ,술후제 1、3천급여 rhEPO (3 000 U/kg)치료,공관찰4 d.주요연구지표유BBB평분、조망지수、염증지수급전경연구.결과:연지응용rhEPO가이억제세포조망,조절염증반응,개선척수손상적초미결구,개선운동공능. 결론:연지응용rhEPO치료대서급성척수손상구유신경보호효응.
Objective To investigate the neuroprotection of delayed treatment of thoracic acute spinal cord injury with recombinant human erythropoietin (rhEPO) in rat model of compressive injury. Methods Sixteen adult male Sprague-Dawley rats were randomly divided into two groups: control group (compressive injury group) and experimental group (rhEPO group), In the compressive injury group,the animals recived 0.9% saline treatment at 2 h, day 1 and day 3 after the injury, while in the rhEPO group, rhEPO (3 000 U/kg) was given to rats at 2 h, day 1 and day 3 after the injury. All the rats were observed in 4 days after the injury. The primary outcomes were evaluated by BBB scale, apoptotic index, inflammatory index and electron microscopy. Results Delayed treatment of thoracic acute spinal cord injury with rhEPO could reduce apoptosis, regulate inflammation, improve motor function and promote regeneration of the spinal cord. Conclusion Our study suggests that delayed treatment of thoracic spinal cord compressive injury with rhEPO could exert neuroprotection.