中国骨质疏松杂志
中國骨質疏鬆雜誌
중국골질소송잡지
Chinese Journal of Osteoporosis
2015年
8期
922-924,944
,共4页
Ⅳ型胶原α1链(COL4A1)%基因%多态性%骨密度
Ⅳ型膠原α1鏈(COL4A1)%基因%多態性%骨密度
Ⅳ형효원α1련(COL4A1)%기인%다태성%골밀도
Collagen type Ⅳ alpha 1 (COL4A1)%Gene%Polymorphism%Bone mineral density
目的 研究COL4A1基因多态性与包头市区女性骨密度的关系. 方法 采用病例-对照研究方法,收集在包头医学院第一附属医院进行健康体检的596例女性流行病学资料,用双能X线吸收仪对研究对象进行骨扫描. 应用PCR-RFLP方法检测COL4A1基因型. 用广义线性模型分析此位点多态性与腰椎及股骨颈骨密度关系. 结果 在调整环境混杂因素前后,均显示COL4A1基因SNPrs3783107突变基因型与绝经前女性股骨颈和腰椎骨密度降低呈显著相关(P=0.011、0.004),但与绝经后的骨密度无显著相关性(P=0.090、0.093). 结论 COL4A1基因SNPrs3783107多态性与包头市区绝经前女性股骨颈及腰椎骨密度显著相关.
目的 研究COL4A1基因多態性與包頭市區女性骨密度的關繫. 方法 採用病例-對照研究方法,收集在包頭醫學院第一附屬醫院進行健康體檢的596例女性流行病學資料,用雙能X線吸收儀對研究對象進行骨掃描. 應用PCR-RFLP方法檢測COL4A1基因型. 用廣義線性模型分析此位點多態性與腰椎及股骨頸骨密度關繫. 結果 在調整環境混雜因素前後,均顯示COL4A1基因SNPrs3783107突變基因型與絕經前女性股骨頸和腰椎骨密度降低呈顯著相關(P=0.011、0.004),但與絕經後的骨密度無顯著相關性(P=0.090、0.093). 結論 COL4A1基因SNPrs3783107多態性與包頭市區絕經前女性股骨頸及腰椎骨密度顯著相關.
목적 연구COL4A1기인다태성여포두시구녀성골밀도적관계. 방법 채용병례-대조연구방법,수집재포두의학원제일부속의원진행건강체검적596례녀성류행병학자료,용쌍능X선흡수의대연구대상진행골소묘. 응용PCR-RFLP방법검측COL4A1기인형. 용엄의선성모형분석차위점다태성여요추급고골경골밀도관계. 결과 재조정배경혼잡인소전후,균현시COL4A1기인SNPrs3783107돌변기인형여절경전녀성고골경화요추골밀도강저정현저상관(P=0.011、0.004),단여절경후적골밀도무현저상관성(P=0.090、0.093). 결론 COL4A1기인SNPrs3783107다태성여포두시구절경전녀성고골경급요추골밀도현저상관.
Objective To investigate the association between genetic polymorphisms of collagen type Ⅳ alpha1 gene ( COL4A1) and bone mineral density ( BMD) in women in Baotou city.Methods Case-control study was used in the research.Epidemiologic data of 596 healthy females were collected from the First Affiliated Hospital of Baotou Medical College.BMD of all subjects was measured using dual-energy X-ray absorptiometry.PCR-restriction fragment length polymorphism ( PCR-RFLP) was applied to examine polymorphisms of the COL 4A1 gene.Generalized linear model was used to analyze the association of polymorphism with BMD of the lumbar spine and the femur.Results Without or with adjustment for environmental covariates, significant correlation was found between the SNP rs3783107 mutation genotype of COL4A1 gene and BMD reduction in the femoral neck and the lumbar spine ( P=0.011, 0.004) in pre-menopause females.No significant correlation was found between mutation genotypes of COL4A1 gene and BMD in post-menopause females ( P =0.090, 0.093 ) .Conclusion There is significant relationship between SNPrs3783107 polymorphism of COL4A1 gene and BMD of the femoral neck and the lumbar spine in pre-menopause women in Baotou city.
