CAJ | 학술논문

目的研究血液病性贫血患者红细胞参数分布规律及其相互关系.方法选取我院收治的120例血液病性贫血患者,均空腹抽取静脉外周血液,采用全自动血细胞分析仪检测患者血清内红细胞参数水平,包括HBG(血红蛋白)、MCV(平均红细胞体积)、RBC(红细胞)、NRBC(有核红细胞)、RDW(红细胞体积分布宽度)水平,研究不同类型血液病性贫血患者MCV、RDW、NRBC比例的分布规律及相互关系. 结果 NHL(非霍杰金氏淋巴瘤)患者与MM(多发性骨髓瘤)患者血清MCV值处于正常范围内,而CML(慢性髓系白血病)、AL(急性白血病)患者MCV>正常值,以MA患者MCV参数增高明显,且与RDW水平同时提升,IDA水平则降低.而HS(遗传性球形细胞贫血)、α地贫(地中海贫血)患者MCV值均低于正常值,但所有患者外周血清NRBC均值明显提升,与MCV、RDW参数有明显相关性. 结论血液病性贫血患者红细胞参数与NRBC、RET比例变化的同步性较强,而其外周NRBC比例的提升与其基本的严重程度及贫血程度相关性较强.
목적 연구혈액병성빈혈환자홍세포삼수분포규률급기상호관계.방법 선취아원수치적120례혈액병성빈혈환자,균공복추취정맥외주혈액,채용전자동혈세포분석의검측환자혈청내홍세포삼수수평,포괄HBG(혈홍단백)、MCV(평균홍세포체적)、RBC(홍세포)、NRBC(유핵홍세포)、RDW(홍세포체적분포관도)수평,연구불동류형혈액병성빈혈환자MCV、RDW、NRBC비례적분포규률급상호관계. 결과 NHL(비곽걸금씨림파류)환자여MM(다발성골수류)환자혈청MCV치처우정상범위내,이CML(만성수계백혈병)、AL(급성백혈병)환자MCV>정상치,이MA환자MCV삼수증고명현,차여RDW수평동시제승,IDA수평칙강저.이HS(유전성구형세포빈혈)、α지빈(지중해빈혈)환자MCV치균저우정상치,단소유환자외주혈청NRBC균치명현제승,여MCV、RDW삼수유명현상관성. 결론 혈액병성빈혈환자홍세포삼수여NRBC、RET비례변화적동보성교강,이기외주NRBC비례적제승여기기본적엄중정도급빈혈정도상관성교강.
Objective To study the distribution law of red blood cell parameters and the relationship in blood disease patients with anemia. Methods 120 cases of blood disease patients with anemia treated in our hospital were selected. Peripheral blood was sampled from the patients on an empty stomach. The automatic blood cell analyzer was used to test red cell parameter levels in patients, including HBG(hemoglobin), MCV (mean corpuscular volume), RBC(red blood cells), NRBC (nucleated red blood cells), RDW( red blood cell volume distribution width) and RET(reticulocytes) level. The distribution law of MCV, RET, RDW, NRBC of different types of blood disease patients with anemia and the ratio of mutual relation were studied.ResultsThe values of CML(chronic myeloid leukemia) and AL (acute leukemia) remained above the normal value. The MCV parameters in patients with MA increased significantly, and improve at the same time with RDW level, but IDA level decreased. The MCV values in patients with HS(geneticspherocytic anemia) and alpha thalassemia were lower than the normal value. But all of the peripheral blood of patients with NRBC enhanced significantly. There was significant correlation with MCV and RDW parameters. Conclusion The synchronization of erythrocyte parameters in blood disease patients with anemia and NRBC, RET ratio change is stronger, but the relativity of the increasing proportion of peripheral NRBC severity and degree of anemia is stronger.