CAJ | 학술논문

SIRT1是Sirtuin家族的一个成员,一种NAD+- 依赖性蛋白去乙酰化酶. SIRT1通过与p53、Ku70、FOXOs、PGC-1A、p300和H1、H3、H4等不同的非组蛋白和组蛋白相互作用来发挥不同的功能. SIRT1基因调控肝脏、脂肪、肌肉、胰岛和脑等器官中的糖脂代谢. SIRT1是脂类稳态的一个重要调节因子,并且对脂肪酸的氧化也起作用. SIRT1自身的表达和活性在转录水平、转录后水平及翻译后水平都受到调控. 本文综述SIRT1基因的表达调控及对动物脂类代谢的功能.
SIRT1시Sirtuin가족적일개성원,일충NAD+- 의뢰성단백거을선화매. SIRT1통과여p53、Ku70、FOXOs、PGC-1A、p300화H1、H3、H4등불동적비조단백화조단백상호작용래발휘불동적공능. SIRT1기인조공간장、지방、기육、이도화뇌등기관중적당지대사. SIRT1시지류은태적일개중요조절인자,병차대지방산적양화야기작용. SIRT1자신적표체화활성재전록수평、전록후수평급번역후수평도수도조공. 본문종술SIRT1기인적표체조공급대동물지류대사적공능.
SIRT1, a member of the Sirtuin family, is a kind of NAD+-dependent histone deacetylase. SIRT1 in?teracts with non-histone proteins and histone such as p53, Ku70, FOXOs, PGC-1A, p300 as well as H1, H3, H4 to exert different functions. SIRT1 gene performs the regulation of glucose and lipid metabolism in the liver, fat, muscle, pancreatic and brain and other organs. SIRT1 is an important regulator of lipid homeostasis factor, and also plays a role in the oxidation of fatty acids. Expression and activity of SIRT1 will be regulated at a tran?scriptional, post-transcriptional and post-translational level respectively, and gene expression regulation and roles for lipid metabolism of sirt1 in animals will be reviewed in this paper.