CAJ | 학술논문

目的:观察存在胰岛素抵抗的2型糖尿病患者采用单纯口服二甲双胍治疗及其与利拉鲁肽联合治疗对患者血糖、GA、HbA1c、体重控制及胰岛素抵抗的影响.方法:2型糖尿病伴胰岛素抵抗患者174例 ,98例给予口服二甲双胍治疗(单药治疗组) ,76例给予口服二甲双胍与皮下注射利拉鲁肽联合治疗(联合治疗组) ,2周后比较空腹血糖、餐后血糖、GA的变化 ,12周后比较HbA1c变化情况、体重下降情况及胰岛素抵抗改善情况.结果:两组血糖、GA、HbA1c较治疗前均下降(P<0 .05).联合治疗组短期及长期血糖控制效果优于单药治疗组(P<0 .05) ,联合治疗组体重下降水平优于单药治疗组(P<0 .05) ,联合治疗组胰岛素抵抗改善程度优于单药治疗组(P<0 .05) ,两组低血糖发生率无统计学差异.结论:对于2型糖尿病合并胰岛素抵抗患者早期联合应用二甲双胍和利拉鲁肽可以更好地控制血糖 ,改善胰岛素抵抗 ,不增加低血糖发生率.
목적:관찰존재이도소저항적2형당뇨병환자채용단순구복이갑쌍고치료급기여리랍로태연합치료대환자혈당、GA、HbA1c、체중공제급이도소저항적영향.방법:2형당뇨병반이도소저항환자174례 ,98례급여구복이갑쌍고치료(단약치료조) ,76례급여구복이갑쌍고여피하주사리랍로태연합치료(연합치료조) ,2주후비교공복혈당、찬후혈당、GA적변화 ,12주후비교HbA1c변화정황、체중하강정황급이도소저항개선정황.결과:량조혈당、GA、HbA1c교치료전균하강(P<0 .05).연합치료조단기급장기혈당공제효과우우단약치료조(P<0 .05) ,연합치료조체중하강수평우우단약치료조(P<0 .05) ,연합치료조이도소저항개선정도우우단약치료조(P<0 .05) ,량조저혈당발생솔무통계학차이.결론:대우2형당뇨병합병이도소저항환자조기연합응용이갑쌍고화리랍로태가이경호지공제혈당 ,개선이도소저항 ,불증가저혈당발생솔.
Objective:To observe the effect of metformin therapy alone and metformin combined with liraglutide thera-py on glycemic control ,glycosylated serum albumin(GA) ,glycosylated hemoglobin (HbA1c) ,weight control and insu-lin resistance in type 2 diabetic patients with insulin resistance .Methods:174 type 2 diabetic patients with insulin resist-ance were enrolled .98 patients were treated with oral metformin treatment .76 patients were treated with oral metform-in combined with liraglutide therapy .The effect of blood glucose control and GA was compared between the two groups after 2 weeks .The effect of HbA1c ,weight control and insulin resistance was compared between the two groups after 12 weeks .Results:Blood sugar ,GA and HbA1c in two groups reduced after therapy(P<0 .05) .Short term and long-term glucose control ,level of weight control and insulin resistance improvement in metformin combined with liraglutide treatment group decreased better than metformin treatment group(P<0 .05) .There was no significant difference in in-cidence of hypoglycemia between the two groups .Conclusion:Early application of metformin and liraglutide in type 2 di-abetic patients with insulin resistance can better control blood glucose ,improve insulin resistance and don't increase the risk of hypoglycemia .