CAJ | 학술논문

目的:探讨不同病理类型胃炎与胃黏膜水通道蛋白3(AQP3)、水通道蛋白4(AQP4)表达的相关性. 方法:胃镜下取胃黏膜,通过普通病理组织学检测胃黏膜病理类型及其活动性,免疫组织学检测AQP3、AQP4表达. 结果:慢性非萎缩性胃炎胃黏膜AQP3、AQP4蛋白表达均明显高于非胃炎组和慢性萎缩性胃炎组,差异有显著性(P < 0.01),其中活动期的慢性非萎缩性胃炎 AQP3、AQP4 蛋白表达升高更为明显,慢性萎缩性胃炎胃黏膜AQP3、AQP4表达低于非胃炎组,但差异无统计学意义,活动期的慢性萎缩性胃炎AQP3表达明显低于非胃炎组,差异有显著性(P < 0.05). 结论:不同病理类型的慢性胃炎胃黏膜AQP3、AQP4表达不同,AQP3、AQP4可能成为不同病理类型的慢性胃炎诊断和治疗的靶点之一.
목적:탐토불동병리류형위염여위점막수통도단백3(AQP3)、수통도단백4(AQP4)표체적상관성. 방법:위경하취위점막,통과보통병리조직학검측위점막병리류형급기활동성,면역조직학검측AQP3、AQP4표체. 결과:만성비위축성위염위점막AQP3、AQP4단백표체균명현고우비위염조화만성위축성위염조,차이유현저성(P < 0.01),기중활동기적만성비위축성위염 AQP3、AQP4 단백표체승고경위명현,만성위축성위염위점막AQP3、AQP4표체저우비위염조,단차이무통계학의의,활동기적만성위축성위염AQP3표체명현저우비위염조,차이유현저성(P < 0.05). 결론:불동병리류형적만성위염위점막AQP3、AQP4표체불동,AQP3、AQP4가능성위불동병리류형적만성위염진단화치료적파점지일.
Objective To explore the correlations of expressions of gastric mucosa water channel aquaporin AQP3 and AQP4 and different gastritis types. Methods The gastric mucosa was mounted under gastroscope. The types of gastric mucosa pathology and activity were tested by the common pathohistology. The expressions of AQP3 and AQP4 were determined by immunohistology. Results The expressions of AQP3 and AQP4 of chronic superficial gastritis were significantly higher than those in the non-gastritis group and chronic atrophic gastritis group (P < 0.01), especially in the activity period of chronic superficial gastritis. The expressions of AQP3 and AQP4 of chronic atrophic gastritis group were reduced when compared to those in the non-gastritis group, in spite of no statistical differences between them. While compared to the non-gastritis group , the expression of AQP3 of chronic atrophic gastritis group during the active stage was remarkably decreased (P < 0.05). Conclusion The expressions of AQP3 and AQP4 of gastric mucosa in chronic gastritis in various pathological types are different. AQP3 and AQP4 may be the targeted point , which could be used for the differential diagnosis and treatment of chronic gastritis of different pathological types.