南方医科大学学报
南方醫科大學學報
남방의과대학학보
Journal of Southern Medical University
2015年
8期
1206-1210
,共5页
高压氧治疗%颅脑损伤后%失语症%疗效观察
高壓氧治療%顱腦損傷後%失語癥%療效觀察
고압양치료%로뇌손상후%실어증%료효관찰
hyperbaric oxygen therapy%craniocerebral injury%aphasia%clinical efficacy
目的 探讨颅脑损伤后失语症患者给予不同压力高压氧治疗(HBO)的临床疗效及治疗依从性.方法 将接受30次HBO治疗的31例颅脑损伤后失语症患者纳入治疗1组;将2009年1月~2011年6月间接受30次HBO治疗的31例颅脑损伤后失语症患者纳入治疗2组;将2009年1月~2013年12月间拒绝HBO治疗的31例颅脑损伤后失语症患者纳入对照组.对照组给予常规的脑外科综合治疗,治疗组在采用综合治疗基础上,治疗1组实施0.175 MPa压力HBO治疗,治疗2组实施0.20 MPa压力HBO治疗.观察3组治疗前后,采用西方失语症成套测验(western aphasia battery, WAB),并对组间WAB各亚项及AQ评分、疗效、失语平均恢复时间、医嘱依从性进行比较.结果 对照组有效率(58.06%)显著低于治疗1组(83.87%)和治疗2组(87.1%).对照组与治疗组WAB各亚项及AQ评分、疗效、失语平均恢复时间比较:差异有统计学意义(P<0.05);治疗组间比较:差异无统计学意义(P>0.05).实施0.175 MPa压力与实施0.20 MPa压力HBO治疗患者医嘱依从性比较:医嘱不依从前者比后者例数减少31.37%,医嘱部分依从增加13.86%,医嘱完全依从增加17.51%,两者差异有统计学意义(P<0.05).结论 HBO治疗颅脑损伤后失语症患者建议采用0.175 MPa的治疗压力,可以确保安全、有效,并能增强患者医嘱依从性.
目的 探討顱腦損傷後失語癥患者給予不同壓力高壓氧治療(HBO)的臨床療效及治療依從性.方法 將接受30次HBO治療的31例顱腦損傷後失語癥患者納入治療1組;將2009年1月~2011年6月間接受30次HBO治療的31例顱腦損傷後失語癥患者納入治療2組;將2009年1月~2013年12月間拒絕HBO治療的31例顱腦損傷後失語癥患者納入對照組.對照組給予常規的腦外科綜閤治療,治療組在採用綜閤治療基礎上,治療1組實施0.175 MPa壓力HBO治療,治療2組實施0.20 MPa壓力HBO治療.觀察3組治療前後,採用西方失語癥成套測驗(western aphasia battery, WAB),併對組間WAB各亞項及AQ評分、療效、失語平均恢複時間、醫囑依從性進行比較.結果 對照組有效率(58.06%)顯著低于治療1組(83.87%)和治療2組(87.1%).對照組與治療組WAB各亞項及AQ評分、療效、失語平均恢複時間比較:差異有統計學意義(P<0.05);治療組間比較:差異無統計學意義(P>0.05).實施0.175 MPa壓力與實施0.20 MPa壓力HBO治療患者醫囑依從性比較:醫囑不依從前者比後者例數減少31.37%,醫囑部分依從增加13.86%,醫囑完全依從增加17.51%,兩者差異有統計學意義(P<0.05).結論 HBO治療顱腦損傷後失語癥患者建議採用0.175 MPa的治療壓力,可以確保安全、有效,併能增彊患者醫囑依從性.
목적 탐토로뇌손상후실어증환자급여불동압력고압양치료(HBO)적림상료효급치료의종성.방법 장접수30차HBO치료적31례로뇌손상후실어증환자납입치료1조;장2009년1월~2011년6월간접수30차HBO치료적31례로뇌손상후실어증환자납입치료2조;장2009년1월~2013년12월간거절HBO치료적31례로뇌손상후실어증환자납입대조조.대조조급여상규적뇌외과종합치료,치료조재채용종합치료기출상,치료1조실시0.175 MPa압력HBO치료,치료2조실시0.20 MPa압력HBO치료.관찰3조치료전후,채용서방실어증성투측험(western aphasia battery, WAB),병대조간WAB각아항급AQ평분、료효、실어평균회복시간、의촉의종성진행비교.결과 대조조유효솔(58.06%)현저저우치료1조(83.87%)화치료2조(87.1%).대조조여치료조WAB각아항급AQ평분、료효、실어평균회복시간비교:차이유통계학의의(P<0.05);치료조간비교:차이무통계학의의(P>0.05).실시0.175 MPa압력여실시0.20 MPa압력HBO치료환자의촉의종성비교:의촉불의종전자비후자례수감소31.37%,의촉부분의종증가13.86%,의촉완전의종증가17.51%,량자차이유통계학의의(P<0.05).결론 HBO치료로뇌손상후실어증환자건의채용0.175 MPa적치료압력,가이학보안전、유효,병능증강환자의촉의종성.
Objective To observe the clinical effect of hyperbaric oxygen (HBO) therapy at different pressure levels on aphasia after craniocerebral injury and assess the patient adherence to the therapies. Methods Thirty-one patients with aphasia after craniocerebral injury receiving 30 sessions of HBO therapy at the pressure level of 0.175 MPa and another 31 patients receiving 0.2 MPa therapy were recruited as the treatment groups 1 and 2, respectively;31 patients who refused to have HBO therapy served as the control group. All the patients received routine therapy. The therapeutic effects were assessed using Western Aphasia Battery (WAB) before and after the therapy. The WAB item and AQ scores, curative effect, and recovery time of aphasia were compared between the 3 groups. Results The total response rate was significantly lower in the control group as compared with those in treatment groups 1 and 2 (58.06% vs 83.87% and 87.1%). WAB item scores and AQ scores, curative effect, and recovery time of aphasia all showed significant differences between the control group and the two treatment groups (P<0.05), but not between the latter 2 groups (P>0.05). Compared with 0.20 MPa HBO therapy, 0.175 MPa HBO therapy showed a better patient adherence with a significantly lowered non-adherence rate (by 31.37%) an increased partial and total adherence rates (by 13.86% and 17.51%, respectively). Conclusion HBO therapy at the pressure level of 0.175 MPa is more appropriate for treatment of aphasia after craniocerebral injury to ensure the safety, efficacy and patient compliance.
