医学理论与实践
醫學理論與實踐
의학이론여실천
The Journal of Medical Theory and Practice
2015年
16期
2135-2137,2154
,共4页
仝太山%兰光华%唐小伟%金彦斌
仝太山%蘭光華%唐小偉%金彥斌
동태산%란광화%당소위%금언빈
结直肠癌%化疗%认知功能%事件相关电位%P300
結直腸癌%化療%認知功能%事件相關電位%P300
결직장암%화료%인지공능%사건상관전위%P300
Colorectal cancer%Chemotherapy%Cognition%Event-related potentials%P300
目的:观察结直肠癌术后化疗患者认知功能损害特征和事件相关电位P300的变化特征.方法:选择数字广度(DS)、连线测验(TMT)、词语流畅性测验(VF)、威斯康星卡片分类测验(WCST)等多项经典神经认知心理学测验及事件相关电位P300分别对51例结直肠癌术后化疗患者和50例健康对照者进行测试 ,并分析神经认知心理学测验成绩与P3波幅及潜伏期的相关性.结果:(1 )病例组数字符号、连线测验、词语流畅性测验、威斯康星卡片分类测验等10个神经心理学测验成绩较对照组差 ,差异有统计学意义(P<0 .05);事件相关电位P300中P3波幅下降 ,P3、N2的潜伏期延长 ,有统计学意义(P<0 .01).(2)神经认知心理学测验结果与P3波幅及潜伏期存在相关性.结论:(1)结直肠癌术后化疗患者存在广泛的认知功能损害 ,主要表现在注意、记忆、执行功能方面.(2 )事件相关电位P300与神经认知心理学测验存在相关性 ,可以作为判断化疗后早期认知损害的指标.
目的:觀察結直腸癌術後化療患者認知功能損害特徵和事件相關電位P300的變化特徵.方法:選擇數字廣度(DS)、連線測驗(TMT)、詞語流暢性測驗(VF)、威斯康星卡片分類測驗(WCST)等多項經典神經認知心理學測驗及事件相關電位P300分彆對51例結直腸癌術後化療患者和50例健康對照者進行測試 ,併分析神經認知心理學測驗成績與P3波幅及潛伏期的相關性.結果:(1 )病例組數字符號、連線測驗、詞語流暢性測驗、威斯康星卡片分類測驗等10箇神經心理學測驗成績較對照組差 ,差異有統計學意義(P<0 .05);事件相關電位P300中P3波幅下降 ,P3、N2的潛伏期延長 ,有統計學意義(P<0 .01).(2)神經認知心理學測驗結果與P3波幅及潛伏期存在相關性.結論:(1)結直腸癌術後化療患者存在廣汎的認知功能損害 ,主要錶現在註意、記憶、執行功能方麵.(2 )事件相關電位P300與神經認知心理學測驗存在相關性 ,可以作為判斷化療後早期認知損害的指標.
목적:관찰결직장암술후화료환자인지공능손해특정화사건상관전위P300적변화특정.방법:선택수자엄도(DS)、련선측험(TMT)、사어류창성측험(VF)、위사강성잡편분류측험(WCST)등다항경전신경인지심이학측험급사건상관전위P300분별대51례결직장암술후화료환자화50례건강대조자진행측시 ,병분석신경인지심이학측험성적여P3파폭급잠복기적상관성.결과:(1 )병례조수자부호、련선측험、사어류창성측험、위사강성잡편분류측험등10개신경심이학측험성적교대조조차 ,차이유통계학의의(P<0 .05);사건상관전위P300중P3파폭하강 ,P3、N2적잠복기연장 ,유통계학의의(P<0 .01).(2)신경인지심이학측험결과여P3파폭급잠복기존재상관성.결론:(1)결직장암술후화료환자존재엄범적인지공능손해 ,주요표현재주의、기억、집행공능방면.(2 )사건상관전위P300여신경인지심이학측험존재상관성 ,가이작위판단화료후조기인지손해적지표.
Objective:Study the character of the cognitive impairment and P300 parameter of patients with colorectal cancer after chemotherapy .Methods:51 patients with colorectal cancer and 50 healthy controls were administered with P300 and a neuropsychological test for cognition ,including digit span ,Trail making test ,Verbal fluency test ,Winscon-sin card sorting test ,etceteva and study the correlation of neuropsychological test and P300 .Results:(1)After chemo-therapy ,patients with colorectal cancer showed significant difference in each targets of cognitive function ,such as digit symbol ,TMT ,verbal fluency test ,total trails of WCST (P<0 .05);the latency of N3 ,P3 of P300 was significantly longer ,the amplitude of P300 was significantly lower(P<0 .01) .(2)The changes of P3PL and P3bAmp were correla-ted with each targets of cognitive test .Conclusion:(1)After chemotherapy ,the cognitive function of patients with color-ectal cancer after chemotherapy had obvious impairment in attention ,memory ,executive functions .(2)P300 and cogni-tive test has fine correlation .P300 can be used as a biological marker of screening cognitive impairment for the patients with colorectal cancer after chemotherapy .
