CAJ | 학술논문

目的评估两种新型聚柠檬酸可降解生物材料诱导大鼠颅骨缺损后软组织再生的能力.方法雄性Sprague Dawley大鼠46只,随机选取6只SD大鼠大腿肌肉分别植入材料,两周后取材;剩余40只颅骨缺损造模后随机分为4组:对照组,自体骨移植组和两种新型柠檬酸材料移植组,每组各10只,处理后3个月取材,行组织学染色及形态计量学分析.结果 1、两种新型聚柠檬酸生物材料可诱导肌肉内软组织再生;2、两种新型聚柠檬酸生物材料可诱导大鼠颅骨缺损时的血管与纤维组织再生;3、两种新型聚柠檬酸生物材料通过诱导软组织再生加速颅骨缺损后膜内成骨发生.结论两种生物材料具有良好的软组织再生诱导性,可有效刺激颅骨缺损时软组织再生并同时加速颅骨膜内成骨的发生最终促进颅骨愈合.
목적 평고량충신형취저몽산가강해생물재료유도대서로골결손후연조직재생적능력.방법 웅성Sprague Dawley대서46지,수궤선취6지SD대서대퇴기육분별식입재료,량주후취재;잉여40지로골결손조모후수궤분위4조:대조조,자체골이식조화량충신형저몽산재료이식조,매조각10지,처리후3개월취재,행조직학염색급형태계량학분석.결과 1、량충신형취저몽산생물재료가유도기육내연조직재생;2、량충신형취저몽산생물재료가유도대서로골결손시적혈관여섬유조직재생;3、량충신형취저몽산생물재료통과유도연조직재생가속로골결손후막내성골발생.결론 량충생물재료구유량호적연조직재생유도성,가유효자격로골결손시연조직재생병동시가속로골막내성골적발생최종촉진로골유합.
Objective To observe the soft tissue regeneration after implantation of two novel citric acid-based biodegradable materials in the skull defects in rats. Methods Two novel citric acid-based biodegradable materials were implanted in the muscular tissues in the thigh and harvested 2 weeks later. Another 40 rats with surgically induced cranial defect were randomized into control group, autograft group, CUPE-HA group, and POC-HA group (n=10), and 3 months after implantation, the materials were harvested for histological and morphometric analyses. Results Soft tissue regeneration was stimulated by the two biodegradable materials in the muscular tissues. The implants also stimulated angiogenesis and soft tissue regeneration in the cranial defect and accelerated of intramembranous ossification. Conclusion The 2 novel citric acid-based biodegradable materials can induce angiogenesis and soft tissue regeneration and accelerate intramembranous ossification in rats with cranial defects.