CAJ | 학술논문

目的:探讨乌榄果、皮水提取物对离体大鼠冠脉流量的影响 ,寻找最有效的药用部位.方法:采用langenendorff离体心脏灌流法 ,通过M edLab生物信号采集处理系统 ,以生理盐水作对照 ,观察乌榄果、皮水提取物对大鼠冠脉流量的影响.结果:给药前 ,各组组间均无显著性统计学差异.在给药后1min起 ,生理盐水对照组冠脉流量呈现递减的趋势 ,10% 乌榄果、皮水提取物组冠脉流量均表现为增加 ,持续至给药后5min ,10min开始减少 ,呈现先增加后减少作用 ,与生理盐水对照组比较有显著性差异( P<0 .05 ) ,10% 乌榄皮水提物组作用与果水提取物相似 ,给药后3min、5min冠脉流量增加与生理盐水对照组比较有显著性差异(P<0 .05).结论:乌榄果、皮水提取物有增加大鼠心脏冠脉流量的作用 ,果水提取物持续作用时间较长.提示乌榄果和皮中含有扩张冠脉作用的活性物质.
목적:탐토오람과、피수제취물대리체대서관맥류량적영향 ,심조최유효적약용부위.방법:채용langenendorff리체심장관류법 ,통과M edLab생물신호채집처리계통 ,이생리염수작대조 ,관찰오람과、피수제취물대대서관맥류량적영향.결과:급약전 ,각조조간균무현저성통계학차이.재급약후1min기 ,생리염수대조조관맥류량정현체감적추세 ,10% 오람과、피수제취물조관맥류량균표현위증가 ,지속지급약후5min ,10min개시감소 ,정현선증가후감소작용 ,여생리염수대조조비교유현저성차이( P<0 .05 ) ,10% 오람피수제물조작용여과수제취물상사 ,급약후3min、5min관맥류량증가여생리염수대조조비교유현저성차이(P<0 .05).결론:오람과、피수제취물유증가대서심장관맥류량적작용 ,과수제취물지속작용시간교장.제시오람과화피중함유확장관맥작용적활성물질.
Objective:Investigate the effect of liquid extract of Canarium pimela Leeth .fruits and liquid extract of Ca-narium pimela Leeth .skin effect on isolated rat ex vivo cardiac perfusion and find the most effective medicinal parts . Methods:Use langenendorff ex vivo cardiac perfusion technique ,through the MedLab biological signal collecting and processing system ,using physiological saline as control ,to observe the effects of Canarium pimela Leeth .fruits ,Cana-rium pimela Leeth .skin extracts on coronary blood flow in rats .Results:Before treatment ,there was no statistical difference between the groups .After administration of 1min ,the coronary blood flow of the physiological saline control group showed a decreasing trend .The coronary blood flow of the 10% liquid extract groups increased until 5min after administration .After administration of 10min began to reduce ,so the effect increased first and then decreased .There was significant difference between the control group with normal saline (P<0.05) ,the 10% liquid extract of Canari-um pimela Leeth .fruits and the 10% liquid extract of Canarium pimela Leeth .skin were similar .After administration of 3min ,5min increase in coronary flow has significant difference between the control group and normal saline (P<0.05) .Conclusion:The liquid extract of Canarium pimela Leeth .fruits and the liquid extract of Canarium pimela Leeth . skin increase the coronary flow of the heart function of rats ,but the liquid extract of Canarium pimela Leeth .fruits was longer duration .Canarium pimela Leeth .fruits and Canarium pimela Leeth .skin contain active substances dilation of coronary artery .