中国医药科学
中國醫藥科學
중국의약과학
China Medicine and Pharmacy
2015年
14期
48-50
,共3页
喘息型支气管炎%儿童%血清25-(OH)D3%IgE水平%临床意义
喘息型支氣管炎%兒童%血清25-(OH)D3%IgE水平%臨床意義
천식형지기관염%인동%혈청25-(OH)D3%IgE수평%림상의의
Asthmatic bronchitis%Children%Serum 25-(OH) D3%IgE level%Clinical significance
目的 探讨小儿喘息型支气管炎血清25羟维生素D3(25-(OH)D3)和总免疫球蛋白E(lgE)的检测及临床意义. 方法 选取2012年8月~2014年8月医院收治的喘息型支气管炎患儿45例、支气管哮喘患儿45例及体检正常儿童40例作为研究对象,均行25-(OH)D3、lgE水平检测.结果 哮喘组25-(OH) D3为(14.68±3.43)ng/mL明显低于喘支炎组(21.25±4.51)ng/mL、正常组(25.41±4.25)ng/mL,喘支炎组明显低于正常组;哮喘组lgE水平为(186.39±1.52)IU/mL明显高于喘支炎组(123.65±16.54)IU/mL、正常组(91.26±15.63)IU/mL,喘支炎组明显高于正常组,差异均具有统计学意义(P<0.05).其中,喘息性支气管炎血清25-(OH)D3与lgE水平无相关性(r=0.29,P>0.05);支气管哮喘血清25-(OH)D3与lgE水平呈负相关关系(r=-7.39,P<0.05).结论 喘息型支气管炎与支气管哮喘相似,存在血清25-(OH)D3缺乏和IgE水平升高,可将补充血清25-(OH)D3作为预防支气管哮喘的辅助疗法.
目的 探討小兒喘息型支氣管炎血清25羥維生素D3(25-(OH)D3)和總免疫毬蛋白E(lgE)的檢測及臨床意義. 方法 選取2012年8月~2014年8月醫院收治的喘息型支氣管炎患兒45例、支氣管哮喘患兒45例及體檢正常兒童40例作為研究對象,均行25-(OH)D3、lgE水平檢測.結果 哮喘組25-(OH) D3為(14.68±3.43)ng/mL明顯低于喘支炎組(21.25±4.51)ng/mL、正常組(25.41±4.25)ng/mL,喘支炎組明顯低于正常組;哮喘組lgE水平為(186.39±1.52)IU/mL明顯高于喘支炎組(123.65±16.54)IU/mL、正常組(91.26±15.63)IU/mL,喘支炎組明顯高于正常組,差異均具有統計學意義(P<0.05).其中,喘息性支氣管炎血清25-(OH)D3與lgE水平無相關性(r=0.29,P>0.05);支氣管哮喘血清25-(OH)D3與lgE水平呈負相關關繫(r=-7.39,P<0.05).結論 喘息型支氣管炎與支氣管哮喘相似,存在血清25-(OH)D3缺乏和IgE水平升高,可將補充血清25-(OH)D3作為預防支氣管哮喘的輔助療法.
목적 탐토소인천식형지기관염혈청25간유생소D3(25-(OH)D3)화총면역구단백E(lgE)적검측급림상의의. 방법 선취2012년8월~2014년8월의원수치적천식형지기관염환인45례、지기관효천환인45례급체검정상인동40례작위연구대상,균행25-(OH)D3、lgE수평검측.결과 효천조25-(OH) D3위(14.68±3.43)ng/mL명현저우천지염조(21.25±4.51)ng/mL、정상조(25.41±4.25)ng/mL,천지염조명현저우정상조;효천조lgE수평위(186.39±1.52)IU/mL명현고우천지염조(123.65±16.54)IU/mL、정상조(91.26±15.63)IU/mL,천지염조명현고우정상조,차이균구유통계학의의(P<0.05).기중,천식성지기관염혈청25-(OH)D3여lgE수평무상관성(r=0.29,P>0.05);지기관효천혈청25-(OH)D3여lgE수평정부상관관계(r=-7.39,P<0.05).결론 천식형지기관염여지기관효천상사,존재혈청25-(OH)D3결핍화IgE수평승고,가장보충혈청25-(OH)D3작위예방지기관효천적보조요법.
Objective To investigate the detection and clinical significance of serum 25 hydroxy Vitamin D3 (25-(OH) D3) and total serum immunoglobulin E (lgE) of pediatric asthmatic bronchial asthma.Methods Selected 45 cases of bronchial asthma children,45 cases of Bronchial asthma children treated in our hospital from August 2012-August 2014,and 40 normal children as the research object,were tested with 25- (OH)D3,lgE level.Results The 25(OH) D3 asthmatic group was (14.68±3.43)ng/mL,was significantly lower than that of asthmatic bronchitis group (21.25±4.51) ng/mL,the normal group (25.41±4.25)ng/mL, asthmatic bronchitis group was significantly lower than that of normal group; asthma group lgE level was (186.39±1.52)IU/mL,was significantly higher than that of asthmatic bronchitis group (123.65±16.54) IU/mL,the normal group was (91.26±15.63) IU/mL,asthmatic bronchitis group was significantly higher than that in normal group,difference was statistically significant (P<0.05).Among them,asthmatic bronchitis in serum 25-(OH) D3 was not associated with lgE level (r=0.29,P>0.05);bronchial asthma serum 25-(OH) D3 was negatively correlated with lgE level (r=-7.39,P<0.05).Conclusion Asthmatic bronchitis and bronchial asthma are similar, the presence of serum 25- (OH) D3 deficiency and IgE level increased, can be added serum 25-(OH) D3 as an adjuvant therapy for prevention of bronchial asthma.
