CAJ | 학술논문

目的运用基于体素的形态学测量(VBM)方法分析三叉神经痛患者(TNP)和正常对照组间全脑灰质体积的差异.方法采用PHILIPS 1.5T磁共振扫描仪对28例TNP患者和28例正常对照进行全脑高分辨结构像扫描.采用SPM8对采集的三维结构像数据进行预处理,利用DARTEL对全脑结构进行VBM分析,并以双样本t检验比较两组被试灰质体积的差异.结果与正常对照组相比,TNP显示双侧大脑半球广泛脑区的灰质体积减少,这些减少的区域主要位于双侧颞中回,双侧额上回,额中回,左侧中央前后回,右侧梭状回,前扣带回等区域.结论 VBM揭示了TNP存在广泛脑区灰质密度异常,这些脑区基本属于疼痛的感知和处理区域.此外,这种脑结构改变有助于对TNP神经机制的探讨.
목적 운용기우체소적형태학측량(VBM)방법분석삼차신경통환자(TNP)화정상대조조간전뇌회질체적적차이.방법채용PHILIPS 1.5T자공진소묘의대28례TNP환자화28례정상대조진행전뇌고분변결구상소묘.채용SPM8대채집적삼유결구상수거진행예처리,이용DARTEL대전뇌결구진행VBM분석,병이쌍양본t검험비교량조피시회질체적적차이.결과 여정상대조조상비,TNP현시쌍측대뇌반구엄범뇌구적회질체적감소,저사감소적구역주요위우쌍측섭중회,쌍측액상회,액중회,좌측중앙전후회,우측사상회,전구대회등구역.결론 VBM게시료TNP존재엄범뇌구회질밀도이상,저사뇌구기본속우동통적감지화처리구역.차외,저충뇌결구개변유조우대TNP신경궤제적탐토.
Objective To investigate the changes in whole brain gray matter volume in patients with trigeminal neuralgia using voxel-based morphometry (VBM). Methods Twenty-eight patients with trigeminal neuralgia and 28 healthy controls underwent magnetic resonance imaging with a Philips 1.5T MRI scanner. VBM was used to compare the structural differences in the whole brain gray matter between the two groups based on the DARTEL after data preprocessing with SPM8 software package. Results Compared with the healthy controls, the patients with trigeminal neuralgia presented with decreased gray matter volume in several brain regions including the bilateral middle temporal gyrus, bilateral superior/middle frontal gyrus, left pre-/post-central gyrus, right fusiform and anterior cingulate gyrus. Conclusions Patients with trigeminal neuralgia had abnormal gray matter volume in some brain regions associated with perception and processing of pain sensation. These changes may provide clues for further exploration of the neuropathogenic basis of trigeminal neuralgia.