中国医院用药评价与分析
中國醫院用藥評價與分析
중국의원용약평개여분석
Evaluation and Analysis of Drug-Use in Hospitals of China
2015年
8期
996-998
,共3页
慢性阻塞性肺疾病%氨茶碱%布地奈德%肺功能%运动耐量
慢性阻塞性肺疾病%氨茶堿%佈地奈德%肺功能%運動耐量
만성조새성폐질병%안다감%포지내덕%폐공능%운동내량
COPD%Aminophylline%Budesonide%Lung function%Exercising tolerance
目的:探讨小剂量氨茶碱联合布地奈德对慢性阻塞性肺疾病( chronic bstructive ulmonary iseases,COPD)患者肺功能及运动耐量的影响. 方法:选取2012年5月-2014年5月收治的102例COPD患者作为研究对象,采用随机数字表法将患者分为对照组和观察组各51例,对照组患者予以布地奈德治疗,观察组患者在对照组基础上予以小剂量氨茶碱治疗,观察2组患者肺功能及运动耐量变化情况,评估临床疗效. 结果:观察组患者总有效率为94. 12%( 48/51 ) ,显著高于对照组76. 47%( 39/51 ) ,差异有统计学意义(P<0. 05);观察组患者治疗后第一秒用力呼气容积、第一秒用力呼气容积与用力肺活量比值、第一秒用力呼气容积占预计值的百分比分别为( 1. 79 ± 0. 41 ) L、( 63. 84 ± 5. 29 )%、( 78. 30 ± 3. 55 )%,均显著高于对照组,差异有统计学意义( P<0. 05);观察组患者治疗后6 min步行距离为(289. 64 ± 36. 27) m,显著长于对照组的(224. 71 ± 33. 58) m,差异有统计学意义(P<0. 05). 结论:小剂量氨茶碱联合布地奈德治疗COPD,能够改善肺功能,缓解运动受限症状,且无明显不良反应.
目的:探討小劑量氨茶堿聯閤佈地奈德對慢性阻塞性肺疾病( chronic bstructive ulmonary iseases,COPD)患者肺功能及運動耐量的影響. 方法:選取2012年5月-2014年5月收治的102例COPD患者作為研究對象,採用隨機數字錶法將患者分為對照組和觀察組各51例,對照組患者予以佈地奈德治療,觀察組患者在對照組基礎上予以小劑量氨茶堿治療,觀察2組患者肺功能及運動耐量變化情況,評估臨床療效. 結果:觀察組患者總有效率為94. 12%( 48/51 ) ,顯著高于對照組76. 47%( 39/51 ) ,差異有統計學意義(P<0. 05);觀察組患者治療後第一秒用力呼氣容積、第一秒用力呼氣容積與用力肺活量比值、第一秒用力呼氣容積佔預計值的百分比分彆為( 1. 79 ± 0. 41 ) L、( 63. 84 ± 5. 29 )%、( 78. 30 ± 3. 55 )%,均顯著高于對照組,差異有統計學意義( P<0. 05);觀察組患者治療後6 min步行距離為(289. 64 ± 36. 27) m,顯著長于對照組的(224. 71 ± 33. 58) m,差異有統計學意義(P<0. 05). 結論:小劑量氨茶堿聯閤佈地奈德治療COPD,能夠改善肺功能,緩解運動受限癥狀,且無明顯不良反應.
목적:탐토소제량안다감연합포지내덕대만성조새성폐질병( chronic bstructive ulmonary iseases,COPD)환자폐공능급운동내량적영향. 방법:선취2012년5월-2014년5월수치적102례COPD환자작위연구대상,채용수궤수자표법장환자분위대조조화관찰조각51례,대조조환자여이포지내덕치료,관찰조환자재대조조기출상여이소제량안다감치료,관찰2조환자폐공능급운동내량변화정황,평고림상료효. 결과:관찰조환자총유효솔위94. 12%( 48/51 ) ,현저고우대조조76. 47%( 39/51 ) ,차이유통계학의의(P<0. 05);관찰조환자치료후제일초용력호기용적、제일초용력호기용적여용력폐활량비치、제일초용력호기용적점예계치적백분비분별위( 1. 79 ± 0. 41 ) L、( 63. 84 ± 5. 29 )%、( 78. 30 ± 3. 55 )%,균현저고우대조조,차이유통계학의의( P<0. 05);관찰조환자치료후6 min보행거리위(289. 64 ± 36. 27) m,현저장우대조조적(224. 71 ± 33. 58) m,차이유통계학의의(P<0. 05). 결론:소제량안다감연합포지내덕치료COPD,능구개선폐공능,완해운동수한증상,차무명현불량반응.
OBJECTIVE:To explore the effect of small dose of aminophylline combined with budesonide on the improvement of lung function and exercising tolerance of patients with chronic obstructive pulmonary diseases ( COPD ) . METHODS:102 patients with COPD from Apr. 2012 to Apr. 2014 were selected as the research objects and were divided into the observation group and the control group by digital random table, with 51 cases in each group. The control group was treated with budesonide while the observation group additionally received small dose of aminophylline on the basis of the control group. Changes of lung function and exercising tolerance of the two groups were observed. The clinical efficacy was evaluated. RESULTS:The effective rate of the observation group was 94. 412%(48/51)which was significantly higher than 76. 47%(39/51) of the control group, the difference was significant (P <0. 05). After treatment, FEV1, FEV1/FV, FEV1% of the observation group respectively were respectively (1. 79 ± 0. 41) L, (63. 84 ± 5. 29)% and (78. 30 ± 3. 55)%which was significantly higher than those of the control group, the difference was statistically significant (P<0. 05). After treatment, 6 MWD of the observation group was (289. 64 ± 36. 27) which was significantly longer than that of the control group [(224. 71 ±33. 58)m], the difference was significant (P<0. 05). CONCLUSIONS:The utilization of small dose of aminophylline combined with budesonide in treatment of COPD can improve lung function, alleviate the symptoms of motion being limited, and there's no obvious adverse drug reaction.
