CAJ | 학술논문

慢性阻塞性肺疾病( chronic obstructive pulmonary disease,COPD)为进行性不完全可逆的气流受限,伴有一些显著的肺外效应,其中包括骨质疏松等疾病,COPD致骨质疏松的发病机制不是很明确,可能与吸烟、低氧、运动减少、使用糖皮质激素等因素有关. 吸烟是COPD的重要发病因素,也是骨质疏松的危险因素,COPD患者体力和耐力下降,运动量不足,骨丢失增多,低氧血症和高碳酸血症引起破骨细胞活性增强,抑制骨形成,在COPD患者中糖皮质激素的应用使得患者骨强度下降,低体重与骨密度密切相关,营养不良可减少营养吸收,炎症因子在骨质疏松中也扮演了重要作用.
만성조새성폐질병( chronic obstructive pulmonary disease,COPD)위진행성불완전가역적기류수한,반유일사현저적폐외효응,기중포괄골질소송등질병,COPD치골질소송적발병궤제불시흔명학,가능여흡연、저양、운동감소、사용당피질격소등인소유관. 흡연시COPD적중요발병인소,야시골질소송적위험인소,COPD환자체력화내력하강,운동량불족,골주실증다,저양혈증화고탄산혈증인기파골세포활성증강,억제골형성,재COPD환자중당피질격소적응용사득환자골강도하강,저체중여골밀도밀절상관,영양불량가감소영양흡수,염증인자재골질소송중야분연료중요작용.
Chronic obstructive pulmonary disease ( COPD) is not completely reversible airflow limited, with some significant extrapulmonary effects, including osteoporosis.The pathogenesis of COPD-induced osteoporosis is not very clear.It may be associated with smoking, low oxygen, reduced movement, use of corticosteroids, and other factors.Smoking is an important risk factor of COPD, and it is also a risk factor for osteoporosis.Physical strength and endurance exercise in COPD patients are insufficient, leading to increase of bone loss.Hypoxemia and hypercapnia cause increase of osteoclast activity and inhibition of bone formation.The application of glucocorticoids in patients with COPD results in bone strength decline.Low weight is closely related to bone mineral density and poor nutrition can reduce nutrient absorption.Inflammatory factors also play an important role in osteoporosis.