中国医药
中國醫藥
중국의약
China Medicine
2015年
9期
1257-1259
,共3页
刘时武%王喜玉%马建林%李斌
劉時武%王喜玉%馬建林%李斌
류시무%왕희옥%마건림%리빈
H型高血压%脂质过氧化损伤%血管内皮功能%临床意义
H型高血壓%脂質過氧化損傷%血管內皮功能%臨床意義
H형고혈압%지질과양화손상%혈관내피공능%림상의의
H type hypertension%Lipid peroxide injury%Vascular endothelial function%Clinical significance
目的 探讨H型高血压患者脂质过氧化损伤和血管内皮功能变化情况.方法 纳入2012年2月至2013年1月海南省人民医院门诊及住院原发性高血压病患者169例,根据血浆同型半胱氨酸(Hcy)水平分为H型高血压组86例(Hcy≥10 μmol/L)和对照组83例(Hcy＜ 10 μmol/L),比较2组24h平均血压、血浆Hcy、丙二醛、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)、谷胱甘肽、一氧化氮、一氧化氮合成酶(NOS)、肱动脉血管内皮依赖性舒张功能(EDFMD)差异.结果 H型高血压组和对照组24 h平均血压差异无统计学意义[(131.6±7.1)/(85.4±2.9) mmHg(1mmHg =0.133 kPa)比(132.1±7.1)/(85.1±3.2)mmHg] (P＞0.05).H型高血压组SOD、GSH-Px、谷胱甘肽、一氧化氮、NOS和EDFMD水平均低于对照组[(81±19) IU/ml比(96±18) IU/ml、(161±28) U/L比(174±27) U/L、(0.8±0.2)mmol/L比(0.9±0.2)mmol/L、(72±15) μmol/L比(82±14) μmol/L、(2.0±0.4) U/ml比(2.7±0.4) U/ml、(9.3±0.9)％比(13.7±0.8)％](均P＜0.05),血浆Hcy和丙二醛水平高于对照组[(13.3±0.8)μmol/L比(7.6±0.6)μmol/L、(12.3±2.9) μmol/L比(9.1 ±3.0)μmol/L](均P＜0.05).结论 H型高血压患者存在脂质过氧化损伤和血管内皮功能障碍,应采取措施积极干预.
目的 探討H型高血壓患者脂質過氧化損傷和血管內皮功能變化情況.方法 納入2012年2月至2013年1月海南省人民醫院門診及住院原髮性高血壓病患者169例,根據血漿同型半胱氨痠(Hcy)水平分為H型高血壓組86例(Hcy≥10 μmol/L)和對照組83例(Hcy＜ 10 μmol/L),比較2組24h平均血壓、血漿Hcy、丙二醛、超氧化物歧化酶(SOD)、穀胱甘肽過氧化物酶(GSH-Px)、穀胱甘肽、一氧化氮、一氧化氮閤成酶(NOS)、肱動脈血管內皮依賴性舒張功能(EDFMD)差異.結果 H型高血壓組和對照組24 h平均血壓差異無統計學意義[(131.6±7.1)/(85.4±2.9) mmHg(1mmHg =0.133 kPa)比(132.1±7.1)/(85.1±3.2)mmHg] (P＞0.05).H型高血壓組SOD、GSH-Px、穀胱甘肽、一氧化氮、NOS和EDFMD水平均低于對照組[(81±19) IU/ml比(96±18) IU/ml、(161±28) U/L比(174±27) U/L、(0.8±0.2)mmol/L比(0.9±0.2)mmol/L、(72±15) μmol/L比(82±14) μmol/L、(2.0±0.4) U/ml比(2.7±0.4) U/ml、(9.3±0.9)％比(13.7±0.8)％](均P＜0.05),血漿Hcy和丙二醛水平高于對照組[(13.3±0.8)μmol/L比(7.6±0.6)μmol/L、(12.3±2.9) μmol/L比(9.1 ±3.0)μmol/L](均P＜0.05).結論 H型高血壓患者存在脂質過氧化損傷和血管內皮功能障礙,應採取措施積極榦預.
목적 탐토H형고혈압환자지질과양화손상화혈관내피공능변화정황.방법 납입2012년2월지2013년1월해남성인민의원문진급주원원발성고혈압병환자169례,근거혈장동형반광안산(Hcy)수평분위H형고혈압조86례(Hcy≥10 μmol/L)화대조조83례(Hcy＜ 10 μmol/L),비교2조24h평균혈압、혈장Hcy、병이철、초양화물기화매(SOD)、곡광감태과양화물매(GSH-Px)、곡광감태、일양화담、일양화담합성매(NOS)、굉동맥혈관내피의뢰성서장공능(EDFMD)차이.결과 H형고혈압조화대조조24 h평균혈압차이무통계학의의[(131.6±7.1)/(85.4±2.9) mmHg(1mmHg =0.133 kPa)비(132.1±7.1)/(85.1±3.2)mmHg] (P＞0.05).H형고혈압조SOD、GSH-Px、곡광감태、일양화담、NOS화EDFMD수평균저우대조조[(81±19) IU/ml비(96±18) IU/ml、(161±28) U/L비(174±27) U/L、(0.8±0.2)mmol/L비(0.9±0.2)mmol/L、(72±15) μmol/L비(82±14) μmol/L、(2.0±0.4) U/ml비(2.7±0.4) U/ml、(9.3±0.9)％비(13.7±0.8)％](균P＜0.05),혈장Hcy화병이철수평고우대조조[(13.3±0.8)μmol/L비(7.6±0.6)μmol/L、(12.3±2.9) μmol/L비(9.1 ±3.0)μmol/L](균P＜0.05).결론 H형고혈압환자존재지질과양화손상화혈관내피공능장애,응채취조시적겁간예.
Objective To evaluate the lipid peroxide injury and vascular endothelial function in patients with H type hypertension.Methods Totally 169 patients with primary hypertension from February 2012 to January 2013 were enrolled and divided into H type hypertension group [homocysteine (Hcy ≥10 μmol/L,86 cases] and control group (Hcy ＜ 10 μmol/L,83 cases).The mean value of 24 hours ambulatory blood pressure,plasma malondialdehyde (MDA),superoxide dismutase (SOD),glutathione peroxidase (GSH-PX),glutathione (GSH),nitric oxide (NO),nitricoxide synthase (NOS),Hcy and endothelium-dependant flowing-mediated dilation (EDFMD) were detected and compared between the two groups.Results There was no significant difference in the mean value of ambulatory blood pressure between H type hypertension group and control group [(131.6 ± 7.1)/(85.4 ± 2.9) mmHg vs (132.1 ± 7.1)/(85.1 ± 3.2) mmHg] (P＞0.05).The levels of SOD,GSH-PX,GSH,NO,NOS and EDFMD in H type hypertension group were all significantly lower than those in control group [(81 ± 19) IU/ml vs (96± 18) IU/ml,(161 ± 28) U/Lvs (174±27) U/L,(0.8±0.2) mmol/L vs (0.9±0.2) mmol/L,(72± 15) μmol/L vs(82 ± 14) μmol/L,(2.0±0.4) U/ml vs (2.7±0.4) U/ml,(9.3±0.9)％ vs (13.7±0.8)％] (all P＜0.05),while MDA and Hcy in H type hypertension group were significantly higher than those in control group [(13.3 ± 0.8) μmol/L vs (7.6 ±0.6) μmol/L,(12.3 ±2.9) μmol/L vs(9.1 ±3.0) μmol/L] (both P ＜0.05).Conclusion Patients with H type hypertension have endothelial dysfunction and lipid peroxidation injury,which should be intervened actively.
