中国医药
中國醫藥
중국의약
China Medicine
2015年
9期
1253-1257
,共5页
陈亚红%刘梅林%乔松%王立羽%李亚瑞
陳亞紅%劉梅林%喬鬆%王立羽%李亞瑞
진아홍%류매림%교송%왕립우%리아서
冠状动脉疾病%左旋肉碱%年龄%高血压
冠狀動脈疾病%左鏇肉堿%年齡%高血壓
관상동맥질병%좌선육감%년령%고혈압
Coronary heart disease%L-carnitine%Age%Hypertension
目的 检测冠状动脉粥样硬化性心脏病(冠心病)患者血浆左旋肉碱水平.方法 纳入2004年10月至2006年3月于北京大学第一医院住院的冠心病患者48例(冠心病组)和非冠心病患者27例(非冠心病组).检测患者血浆总左旋肉碱、游离左旋肉碱水平,计算脂酰左旋肉碱及脂酰左旋肉碱占总左旋肉碱百分比.结果 冠心病组血浆总左旋肉碱水平高于非冠心病组,差异有统计学意义[(63.1±11.6)μmol/L比(51.6±10.9)μmol/L] (P ＜0.05),游离左旋肉碱、脂酰左旋肉碱、脂酰左旋肉碱/总左旋肉碱在冠心病组和非冠心病组间差异无统计学意义[(53.4±11.7) μmol/L比(51.0±3.8)μmol/L、(12.3±5.0) μmol/L比(8.3 ±2.3)μmol/L、(19.4±7.2)％比(13.8±2.5)％](P＞0.05).多重线性回归结果表明冠心病、高血压及年龄为血浆总左旋肉碱水平影响因素(复相关系数R2为0.428,校正复相关系数R2为0.374,P＜0.01).51～60岁患者脂酰左旋肉碱/总左旋肉碱明显高于61 ～70岁患者[(26.3±l3.3)％比(13.6±3.2)％],差异有统计学意义(P＜0.05).高血压患者与非高血压患者间总左旋肉碱、游离左旋肉碱、脂酰左旋肉碱及脂酰左旋肉碱/总左旋肉碱差异无统计学意义(P＞0.05).结论冠心病患者血浆总左旋肉碱水平升高.
目的 檢測冠狀動脈粥樣硬化性心髒病(冠心病)患者血漿左鏇肉堿水平.方法 納入2004年10月至2006年3月于北京大學第一醫院住院的冠心病患者48例(冠心病組)和非冠心病患者27例(非冠心病組).檢測患者血漿總左鏇肉堿、遊離左鏇肉堿水平,計算脂酰左鏇肉堿及脂酰左鏇肉堿佔總左鏇肉堿百分比.結果 冠心病組血漿總左鏇肉堿水平高于非冠心病組,差異有統計學意義[(63.1±11.6)μmol/L比(51.6±10.9)μmol/L] (P ＜0.05),遊離左鏇肉堿、脂酰左鏇肉堿、脂酰左鏇肉堿/總左鏇肉堿在冠心病組和非冠心病組間差異無統計學意義[(53.4±11.7) μmol/L比(51.0±3.8)μmol/L、(12.3±5.0) μmol/L比(8.3 ±2.3)μmol/L、(19.4±7.2)％比(13.8±2.5)％](P＞0.05).多重線性迴歸結果錶明冠心病、高血壓及年齡為血漿總左鏇肉堿水平影響因素(複相關繫數R2為0.428,校正複相關繫數R2為0.374,P＜0.01).51～60歲患者脂酰左鏇肉堿/總左鏇肉堿明顯高于61 ～70歲患者[(26.3±l3.3)％比(13.6±3.2)％],差異有統計學意義(P＜0.05).高血壓患者與非高血壓患者間總左鏇肉堿、遊離左鏇肉堿、脂酰左鏇肉堿及脂酰左鏇肉堿/總左鏇肉堿差異無統計學意義(P＞0.05).結論冠心病患者血漿總左鏇肉堿水平升高.
목적 검측관상동맥죽양경화성심장병(관심병)환자혈장좌선육감수평.방법 납입2004년10월지2006년3월우북경대학제일의원주원적관심병환자48례(관심병조)화비관심병환자27례(비관심병조).검측환자혈장총좌선육감、유리좌선육감수평,계산지선좌선육감급지선좌선육감점총좌선육감백분비.결과 관심병조혈장총좌선육감수평고우비관심병조,차이유통계학의의[(63.1±11.6)μmol/L비(51.6±10.9)μmol/L] (P ＜0.05),유리좌선육감、지선좌선육감、지선좌선육감/총좌선육감재관심병조화비관심병조간차이무통계학의의[(53.4±11.7) μmol/L비(51.0±3.8)μmol/L、(12.3±5.0) μmol/L비(8.3 ±2.3)μmol/L、(19.4±7.2)％비(13.8±2.5)％](P＞0.05).다중선성회귀결과표명관심병、고혈압급년령위혈장총좌선육감수평영향인소(복상관계수R2위0.428,교정복상관계수R2위0.374,P＜0.01).51～60세환자지선좌선육감/총좌선육감명현고우61 ～70세환자[(26.3±l3.3)％비(13.6±3.2)％],차이유통계학의의(P＜0.05).고혈압환자여비고혈압환자간총좌선육감、유리좌선육감、지선좌선육감급지선좌선육감/총좌선육감차이무통계학의의(P＞0.05).결론관심병환자혈장총좌선육감수평승고.
Objective To explore the level of plasma L-carnitine in patients with coronary heart disease (CHD).Methods Totally 75 patients including 48 cases with CHD (CHD group) and 27 cases without CHD (non-CHD group) were enrolled.The levels of total and free L-carnitine were measured,then the percentage of acyl L-carnitine and acyl L-carnitin for total L-carnitine in plasma were calculated and compared between the two groups.Results The plasma level of total L-carnitine in CHD group was significantly higher than that in non-CHD group [(63.1 ± 11.6) μmol/l vs (51.6 ± 10.9) μmol/l] (P ＜ 0.05),while no significant differences of free L-carnitine,acyl L-carnitine and percentage of acyl carnitin for total L-carnitine were found between CHD group and non-CHD group [(53.4± 11.7) μmol/L vs (51.0±3.8) μmoL/L,(12.3±5.0) μmol/L vs (8.3 ± 2.3) μmol/L,(19.4 ± 7.2) ％ vs (13.8 ± 2.5) ％] (P ＞ 0.05).Multiple linear regression showed that CHD,hypertension and age were the influence factors of total L-carnitine (multiple correlation coefficient R2 was 0.428,adjusted multiple correlation coefficient R2 was 0.374,P ＜ 0.01).The percentage of acyl L-carnitine for total L-carnitine was significantly higher in 51-60 years old patients than that in 61-70 years old patients [(26.3 ± 13.3) ％ vs (13.6 ± 3.2) ％] (P ＜ 0.05).No significant differences of total L-carnitine,free L-carnitine,acyl L-carnitine and percentage of acyl carnitin for total L-carnitine were found between hypertension and non hypertension patients (P ＞ 0.05).Conclusion The level of plasma total L-carnitine is increased significantly in CHD patients.
