CAJ | 학술논문

目的评判金天格胶囊( JTG)的短期疗效及观察其对骨转化标志物的影响. 方法志愿加入金天格胶囊疗效评估的44名本院职工,按双能X线( DEXA)的检测结果分为骨密度( Bone Mineral Density,BMD)异常组与正常对照组,均连续服用金天格胶囊1个月. 用药前后检测骨转化生化指标:总Ⅰ型胶原氨基端延长肽( PINP)、β胶联降解产物(β-CTX). 疗程结束后,用数字模拟评分法( VAS)评定短期疗效;组内及组间比较采用t检验,比较PINP、β-CTX的变化情况. 结果金天格胶囊治疗后,BMD异常组的酸痛不适症状显著缓解;BMD正常组的PINP、β-CTX与治疗前无明显差异;BMD异常组PINP增加,β-CTX稍减低. 结论金天格胶囊具有双向调节作用,可以在短时间内促进成骨细胞活性,抑制破骨细胞,有助于维持骨形成与骨吸收的动态平衡.
목적 평판금천격효낭( JTG)적단기료효급관찰기대골전화표지물적영향. 방법 지원가입금천격효낭료효평고적44명본원직공,안쌍능X선( DEXA)적검측결과분위골밀도( Bone Mineral Density,BMD)이상조여정상대조조,균련속복용금천격효낭1개월. 용약전후검측골전화생화지표:총Ⅰ형효원안기단연장태( PINP)、β효련강해산물(β-CTX). 료정결속후,용수자모의평분법( VAS)평정단기료효;조내급조간비교채용t검험,비교PINP、β-CTX적변화정황. 결과 금천격효낭치료후,BMD이상조적산통불괄증상현저완해;BMD정상조적PINP、β-CTX여치료전무명현차이;BMD이상조PINP증가,β-CTX초감저. 결론 금천격효낭구유쌍향조절작용,가이재단시간내촉진성골세포활성,억제파골세포,유조우유지골형성여골흡수적동태평형.
Objective To evaluate the short-term efficacy of Jintiange capsules ( JTG) and to observe its effect on bone turnover markers.Methods Forty-four volunteers were recruited in JTG efficacy study from our hospital.They were divided into bone mineral density ( BMD) abnormal group and normal control group, according to the measurement results using dual energy X-ray absorptiometry ( DEXA) .They all received JTG for 1 month.Biochemical indexes of bone turnover, including procollagen type I intact N-terminal propeptide ( PINP) andβ-C-terminal telopeptides of type 1 collagen (β-CTX) , were measured before and after the treatment.After the treatment, the short-term efficacy was evaluated using visual analogue score ( VAS) .The changes of PINP andβ-CTX between two groups before and after the treatment were compared using Student ' s t test.Results After JTG treatment, the symptoms of pain or discomfort in muscles were significantly alleviated.PINP and β-CTX in BMD normal group showed no significant difference comparing with that before the treatment.In BMD abnormal group, PINP increased and β-CTX decreased slightly.Conclusion JTG has dual-directional regulation function.It promotes the activity of osteoblasts, inhibits the activity of osteoclasts, and maintains the dynamic balance of bone formation and bone resorption.