CAJ | 학술논문

目的探讨唑来膦酸注射液(ZOL)治疗绝经后女性2型糖尿病(T2DM)骨质疏松患者的临床疗效. 方法随机选择在我院内分泌科住院治疗的62例绝经后女性2型糖尿病骨质疏松患者,所有患者均给予唑来膦酸注射液治疗6个月;双能X线骨密度测定仪测定腰椎L1-4、股骨颈、股骨大转子、华氏三角区;原装进口试剂盒检测血清中骨钙素( BGP)和骨特异性碱性磷酸酶( B-ALP);全自动生化分析仪检测肾功能及血钙、血磷;对比治疗前后腰椎L1-4、股骨颈、股骨大转子、华氏三角区的骨密度( BMD)及治疗前后血清中血钙( Ca)、血磷( P)、骨钙素( BGP)、骨特异性碱性磷酸酶( B-ALP);测定治疗前后视觉模拟疼痛评分( VAS). 结果 ZOL治疗6个月后,腰椎L1-4、股骨颈、股骨大转子、华氏三角区的BMD均较前明显升高,差异具有统计学意义(P<0.05);BGP较治疗前明显升高,差异具有统计学意义(P<0.05);B-ALP较治疗前明显降低,差异具有统计学意义(P<0.05);血钙(Ca)、血磷(P)保持平稳,无明显变化(P>0.05);VAS评分改善明显,差异具有统计学意义(P<0.05).结论唑来膦酸注射液(ZOL)治疗绝经后女性2型糖尿病(T2DM)骨质疏松患者疗效确切,值得推广.
목적 탐토서래련산주사액(ZOL)치료절경후녀성2형당뇨병(T2DM)골질소송환자적림상료효. 방법 수궤선택재아원내분비과주원치료적62례절경후녀성2형당뇨병골질소송환자,소유환자균급여서래련산주사액치료6개월;쌍능X선골밀도측정의측정요추L1-4、고골경、고골대전자、화씨삼각구;원장진구시제합검측혈청중골개소( BGP)화골특이성감성린산매( B-ALP);전자동생화분석의검측신공능급혈개、혈린;대비치료전후요추L1-4、고골경、고골대전자、화씨삼각구적골밀도( BMD)급치료전후혈청중혈개( Ca)、혈린( P)、골개소( BGP)、골특이성감성린산매( B-ALP);측정치료전후시각모의동통평분( VAS). 결과 ZOL치료6개월후,요추L1-4、고골경、고골대전자、화씨삼각구적BMD균교전명현승고,차이구유통계학의의(P<0.05);BGP교치료전명현승고,차이구유통계학의의(P<0.05);B-ALP교치료전명현강저,차이구유통계학의의(P<0.05);혈개(Ca)、혈린(P)보지평은,무명현변화(P>0.05);VAS평분개선명현,차이구유통계학의의(P<0.05).결론 서래련산주사액(ZOL)치료절경후녀성2형당뇨병(T2DM)골질소송환자료효학절,치득추엄.
Objective To exploring the clinical efficacy of zoledronic acid ( ZOL ) on the treatment of postmenopausal osteoporosis in women with type 2 diabetes.Methods Sixty-two postmenopausal women with osteoporosis and type 2 diabetes in the endocrinology department of Mianyang Central Hospital were randomly selected.They were treated with zoledronic acid injection for 6 months.Bone mineral density ( BMD) of the lumbar spine, femoral neck, femoral greater trochanter, and Ward' s triangle were detected using dual energy X-ray absorptiometry.BGP and B-ALP were detected using imported kit.Serum Ca and P were detected using automatic biochemical analyzer.The data before and after the treatment were compared.VAS score before and after the treatment was measured.Results BMD of the lumbar spine, femoral neck, femoral greater trochanter, and Ward' s triangle increased significantly after 6-month treatment (p<0.05).The level of BGP increased, but the level of BGP decreased significantly (p<0.05).The levels of serum Ca and P had no change (p>0.05).The VAS decreased significantly (p<0.05).Conclusion The efficacy of ZOL for postmenopausal osteoporosis in women with type 2 diabetes is confirmed and is worth of applying.