CAJ | 학술논문

目的:探讨长期0.18 MPa 氧分压对机体氧化应激指标的影响. 方法:观察16 例健康志愿者、58例突发性耳聋患者分别在常压下、0.18 MP 氧分压下长期重复高压氧(HBO)暴露时,周围静脉血中氧化应激指标(丙二醛、高级氧化蛋白产物和超氧化物歧化酶)的变化. 结果:连续 5、10、20、30 次 0.18 MPa 的HBO 暴露后(1次/d,5 次/周),健康志愿者对照组与突发性耳聋组观察对象的血清内丙二醛、高级氧化蛋白产物和超氧化物歧化酶与治疗前、与突发性耳聋综合治疗相比,差异均无统计学意义(P > 0.05). 结论:长期低压力(0.18 MPa)HBO 暴露对氧化应激正常的健康对象和突发性耳聋患者没有影响;对氧化应激反应异常者的影响需进一步研究.
목적:탐토장기0.18 MPa 양분압대궤체양화응격지표적영향. 방법:관찰16 례건강지원자、58례돌발성이롱환자분별재상압하、0.18 MP 양분압하장기중복고압양(HBO)폭로시,주위정맥혈중양화응격지표(병이철、고급양화단백산물화초양화물기화매)적변화. 결과:련속 5、10、20、30 차 0.18 MPa 적HBO 폭로후(1차/d,5 차/주),건강지원자대조조여돌발성이롱조관찰대상적혈청내병이철、고급양화단백산물화초양화물기화매여치료전、여돌발성이롱종합치료상비,차이균무통계학의의(P > 0.05). 결론:장기저압력(0.18 MPa)HBO 폭로대양화응격정상적건강대상화돌발성이롱환자몰유영향;대양화응격반응이상자적영향수진일보연구.
Objective To evaluate the levels of oxidative stress in patients undergoing long-term and repetitive exposure to hyperbaric oxygen (HBO) treatment. Methods 16 healthy volunteers and 58 patients with sub-acute sudden hearing loss (SHL) exposed to HBO were included in the study. Oxidative stress indices (malondialdehyde, MDA, advanced oxidation protein products, AOPP; superoxide dismutase, SOD) were measured in peripheral blood samples collected at the 5th,10th, 20th and 30th HBO treatments sessions (PO2 0.18 MPa, 1 session per day and 5 sessions per week) and under normal ambient pressure respectively. Results After 5th,10th, 20th and 30th sessions of HBOT, no relevant differences in these three indices were detected compared to pre-HBO exposure, between healthy volunteers (P > 0.05). Conclusions The long-term repetitive HBO treatment for 0.18 MPa of PO2 and 30 sessions could not affect in particular the response of the oxidative stress in healthy persons and patients with sub-acute SHL. The influence on three indices of patients with abnormal situation of oxidative stress undergoing lower pressure of HBO (0.18 MPa) is under investigation.