实用医学杂志
實用醫學雜誌
실용의학잡지
The Journal of Practical Medicine
2015年
16期
2662-2665
,共4页
宫颈肿瘤%中性粒细胞与淋巴细胞比值%预后
宮頸腫瘤%中性粒細胞與淋巴細胞比值%預後
궁경종류%중성립세포여림파세포비치%예후
Cervical cancer%Neutrophil-to-lymphocyte ratio (NLR)%Prognosis
目的:探讨术前中性粒细胞与淋巴细胞比值( NLR )在宫颈癌根治术患者预后评估中的价值. 方法:回顾性分析 2007-2009 年我院 76 例行宫颈癌根治术患者的临床资料,术前均未接受放化疗. 以中位数 NLR = 1 . 94 作为临界值,分为低 NLR ( NLR < 1 . 94 )和高 NLR ( NLR≥1 . 94 )两组,对两组临床病理特征进行比较,单因素及 Cox 多因素评估 NLR 对宫颈癌预后的影响. 结果:两组患者在深肌层浸润、淋巴结转移、病理分级及临床分期的差异有统计学意义(P < 0.05). 单因素分析结果:NLR、临床分期、淋巴结转移及术后辅助治疗是患者预后的影响因素(P < 0.05).Cox 多因素分析结果:NLR、临床分期和淋巴结转移是影响患者无瘤生存期独立因素(P < 0.05),临床分期和淋巴结转移是影响患者总生存期的独立因素( P < 0 . 05 ). 结论:术前高 NLR 可作为宫颈癌根治术后复发的独立因素,但并不是其预后独立因素.
目的:探討術前中性粒細胞與淋巴細胞比值( NLR )在宮頸癌根治術患者預後評估中的價值. 方法:迴顧性分析 2007-2009 年我院 76 例行宮頸癌根治術患者的臨床資料,術前均未接受放化療. 以中位數 NLR = 1 . 94 作為臨界值,分為低 NLR ( NLR < 1 . 94 )和高 NLR ( NLR≥1 . 94 )兩組,對兩組臨床病理特徵進行比較,單因素及 Cox 多因素評估 NLR 對宮頸癌預後的影響. 結果:兩組患者在深肌層浸潤、淋巴結轉移、病理分級及臨床分期的差異有統計學意義(P < 0.05). 單因素分析結果:NLR、臨床分期、淋巴結轉移及術後輔助治療是患者預後的影響因素(P < 0.05).Cox 多因素分析結果:NLR、臨床分期和淋巴結轉移是影響患者無瘤生存期獨立因素(P < 0.05),臨床分期和淋巴結轉移是影響患者總生存期的獨立因素( P < 0 . 05 ). 結論:術前高 NLR 可作為宮頸癌根治術後複髮的獨立因素,但併不是其預後獨立因素.
목적:탐토술전중성립세포여림파세포비치( NLR )재궁경암근치술환자예후평고중적개치. 방법:회고성분석 2007-2009 년아원 76 례행궁경암근치술환자적림상자료,술전균미접수방화료. 이중위수 NLR = 1 . 94 작위림계치,분위저 NLR ( NLR < 1 . 94 )화고 NLR ( NLR≥1 . 94 )량조,대량조림상병리특정진행비교,단인소급 Cox 다인소평고 NLR 대궁경암예후적영향. 결과:량조환자재심기층침윤、림파결전이、병리분급급림상분기적차이유통계학의의(P < 0.05). 단인소분석결과:NLR、림상분기、림파결전이급술후보조치료시환자예후적영향인소(P < 0.05).Cox 다인소분석결과:NLR、림상분기화림파결전이시영향환자무류생존기독립인소(P < 0.05),림상분기화림파결전이시영향환자총생존기적독립인소( P < 0 . 05 ). 결론:술전고 NLR 가작위궁경암근치술후복발적독립인소,단병불시기예후독립인소.
Objective To investigate the value of neutrophil-to-lymphocyte ratio in evaluation of prognosis in patients with early cervical cancer before radical resection. Methods A restropective study was performed in 76 patients who underwent radical resection for early cervical cancer in our hospital between 2007 and 2009. All patients were diagnosed by pathology. All patients did not accept neoadjuvant therapy , the median value of neutrophit-to-lymphocyte ratio (NLR) was 1.94 (0.73-9.31 in range). Based on this value of 1.94 as threshold, all patients were divided into 2 groups: a low NLR(≤1.94, n=38) group and a high NLR ( >1.94, n=38) group. Univariate and multivariate analyses were performed to assess the effectiveness of preoperative NLR to the prognosis in patients who underwent radical hysterectomy combined with pelvic lymph node dissection. Results The preoperative NLR was different significantly in the depth of stromal infiltration, lymphatic metastas, FIGO stage and pathological type between the low NLR group and the high NLR group. The high NLR group, lymphatic metastas, postoperative radiotherapy and FIGO stageⅡ were all risk factors for prognosis and disease-free survival in univariate analysis.Multivariate analysis revealed that NLR, lymphatic metastas and FIGO stageⅡwere independent risk factors for disease-free survival. FIGO stageⅡand lymphatic metastasis were independent risk factors for overall survivaI. Conclusion Preoperative NLR was found to correlate to unfavorable histopathologic features of cervical cancer. The preoperative NLR may be used as a useful and easy biomarker for disease-free survival in patients with cervical cancer, but not an independent risk factor for poor prognosis.