CAJ | 학술논문

目的:观察急性胰腺炎(AP)患者血清中和肽素浓度的变化,探讨和肽素在(AP)诊断和预后判断中的作用. 方法:63例AP患者入选,其中轻型急性胰腺炎(MAP)35例,重症急性胰腺炎(SAP)28例. 研究对象于入院第 1、2、3 天抽血检测和肽素浓度,并收集临床病死率、局部并发症发生率数据进行分析.另以30例正常健康人的血清和肽素浓度作为对照. 结果:AP 患者就诊时血清和肽素浓度比正常健康人明显升高(P < 0.05). SAP患者血清和肽素水平高于同时段的AP(P < 0.05). SAP患者的血清和肽素浓度与患者死亡和局部并发症发生呈正相关(P < 0.01). 结论:和肽素在MAP患者起病早期即明显升高,并与疾病的严重程度密切相关,可以作为AP早期诊断和判断预后的血清学指标.
목적:관찰급성이선염(AP)환자혈청중화태소농도적변화,탐토화태소재(AP)진단화예후판단중적작용. 방법:63례AP환자입선,기중경형급성이선염(MAP)35례,중증급성이선염(SAP)28례. 연구대상우입원제 1、2、3 천추혈검측화태소농도,병수집림상병사솔、국부병발증발생솔수거진행분석.령이30례정상건강인적혈청화태소농도작위대조. 결과:AP 환자취진시혈청화태소농도비정상건강인명현승고(P < 0.05). SAP환자혈청화태소수평고우동시단적AP(P < 0.05). SAP환자적혈청화태소농도여환자사망화국부병발증발생정정상관(P < 0.01). 결론:화태소재MAP환자기병조기즉명현승고,병여질병적엄중정도밀절상관,가이작위AP조기진단화판단예후적혈청학지표.
Objective To investigate the serum copeptin level in patients with acute pancreatitis and explore its clinical significance. Methods Sixty-three patients with acute pancreatitis were enrolled , 35 of which were diagnosed as mild acute pancreatitis (MAP), and the other 28 patients were diagnosed as severe acute pancreatitis (SAP). Serum copeptin levels of all patients were determined on admission , on the second day and the third day after admission, respectively. Thirty healthy subjects were enrolled as the control group. Results Serum copeptin level was obviously higher in patients with SAP than the healthy individuals (P < 0.05), and was also significantly higher in the SAP patients than in the MAP patients (P < 0.05). Moreover, the serum copeptin level in SAP patients was highly associated with mortality and local complication (P < 0.01). Conclusion Serum copeptin level was increased at the early stage of acute pancreatitis and was associated with disease severity, which made it a potential diagnostic and prognostic marker for acute pancreatitis.