CAJ | 학술논문

目的:探讨复合辅酶对2型心肾综合征患者心肾功能的影响.方法:选取2013年6月至2014年12月入住南方医科大学珠江医院心血管内科的2型心肾综合征患者62例,随机分为常规治疗组和复合辅酶组,每组各31例. 其中,复合辅酶组在常规治疗组基础上予以复合辅酶400 U/d静脉滴注,持续2周;以纽约心功能分级、心脏超声、外周血BNP评估心功能变化,外周血肌酐水平、尿量评估肾功能变化. 结果:与常规治疗组相比,复合辅酶组纽约心功能分级Ⅲ、Ⅳ级患者比例减少、LVEF升高、外周血BNP水平降低(P <0.05);复合辅酶组肌酐水平降低、尿量增加(P<0.05). 结论:复合辅酶能够有效改善2型心肾综合征患者心、肾功能.
목적:탐토복합보매대2형심신종합정환자심신공능적영향.방법:선취2013년6월지2014년12월입주남방의과대학주강의원심혈관내과적2형심신종합정환자62례,수궤분위상규치료조화복합보매조,매조각31례. 기중,복합보매조재상규치료조기출상여이복합보매400 U/d정맥적주,지속2주;이뉴약심공능분급、심장초성、외주혈BNP평고심공능변화,외주혈기항수평、뇨량평고신공능변화. 결과:여상규치료조상비,복합보매조뉴약심공능분급Ⅲ、Ⅳ급환자비례감소、LVEF승고、외주혈BNP수평강저(P <0.05);복합보매조기항수평강저、뇨량증가(P<0.05). 결론:복합보매능구유효개선2형심신종합정환자심、신공능.
Objective To investigate the effect of coenzyme complex on the cardiac and renal functions of patients with type 2 cardiorenal syndrome. Methods Sixty-two patients with type 2 cardiorenal syndrome were enrolled in from June 2013 to December 2014 in Zhujiang Hospital , Southern Medical University. These patients divided were into routine group (n = 31) and coenzyme complex (n = 31). The therapy scheme of coenzyme complex group was on the basis of routine group with coenzyme complex intravenous drip , 400 U/day for 2 weeks. The cardiac function was determined by New York Heart Function Assessment, and the cardiac ultrasound, the levels of BNP. The renal function was determined by serum creatinine and urine volume. Results Compared with routine group, the rates of NYHA Ⅲ and Ⅳ were reduced, the LVEF levels were increased and the levels of BNP were increased (P < 0.05). The serum creatinine was decreased and urine volume were increased in the coenzyme complex group (P<0.05). Conclusion Coenzyme complex could improve the cardiac and renal functions of the patients with type 2 cardiorenal syndrome.