CAJ | 학술논문

目的:探讨子宫内膜癌患者血清中叶酸受体α(FRA)的表达情况及其临床应用意义. 方法:收集37例子宫内膜癌、33例子宫内膜增生症及10例正常内膜组织患者的血清标本,采用ELISA法对其表达情况进行检测. 分析各组血清FRA的表达情况和差异,以及血清FRA的表达水平与子宫内膜癌临床病理特征的关系. 结果:在正常人及子宫内膜病变患者血清中均可检测到FRA的表达. 血清FRA在正常组、子宫内膜增生症组、子宫内膜癌组的表达水平逐步升高,且差异具有统计学意义(P < 0.05). 子宫内膜癌组中,血清FRA的表达水平在FIGO分期、肌层浸润深度方面的比较,差异有统计学意义(P < 0.05). 而在不同年龄、绝经与否、肿瘤的分化程度等方面比较,差异无统计学意义(P > 0.05). 结论:血清中能检测到FRA的表达,其表达水平可能有助于子宫内膜癌的诊断、治疗及预后情况的判断.
목적:탐토자궁내막암환자혈청중협산수체α(FRA)적표체정황급기림상응용의의. 방법:수집37례자궁내막암、33례자궁내막증생증급10례정상내막조직환자적혈청표본,채용ELISA법대기표체정황진행검측. 분석각조혈청FRA적표체정황화차이,이급혈청FRA적표체수평여자궁내막암림상병리특정적관계. 결과:재정상인급자궁내막병변환자혈청중균가검측도FRA적표체. 혈청FRA재정상조、자궁내막증생증조、자궁내막암조적표체수평축보승고,차차이구유통계학의의(P < 0.05). 자궁내막암조중,혈청FRA적표체수평재FIGO분기、기층침윤심도방면적비교,차이유통계학의의(P < 0.05). 이재불동년령、절경여부、종류적분화정도등방면비교,차이무통계학의의(P > 0.05). 결론:혈청중능검측도FRA적표체,기표체수평가능유조우자궁내막암적진단、치료급예후정황적판단.
Objective To detect serum concentration of folate receptor alpha and to investigate its significance in the clinical application of patients with endometrial carcinoma. Methods Thirty-seven patients with endometrial carcinoma, 33 patients with endometrial hyperplasia and 10 healthy women were enrolled in this study. Sera were used to detect the the folate receptor alpha using an Enzyme-linked Immunosorbent Assay (ELISA) technique.The expression level of serum folate receptor alpha in different groups was analyzed. The correlation between the expression level of serum folate receptor alpha and age of patients, menopause, tumor morphology, myometrial invasion and clinical stage was was also analyzed in patients with endometrial carcinoma. Results Level of folate receptor alpha was successfully detected in serum of healthy women and patients with endometrial diseases. Level of folate receptor alpha in patients with endometrial carcinoma was much higher than that in patients with endometrial hyperplasia. Level of folate receptor alpha in patients with endometrial hyperplasia was also higher than that in the healthy controls, with significant difference (P < 0.05). In the endometrial carcinoma group,the levle of folate receptor alpha in serum was correlated with the clinical stage and myometrial invasion (P < 0.05), however, Level of folate receptor alpha was not correlated with the age of patients, menopause andtumor morphology(P > 0.05). Conclusion The Serum level of folate receptor alpha can be detected, and its expression will contribute to the diagnosis, treatment and predicting the prognosis of patients with endometrial carcinoma.